Molecular Engineering for Production of Anti-cancer Compounds in Plant Cell Culture Location: 305 Shillman Hall Abstract: Our research is focused on cellular engineering and design of bioprocesses using plant-based systems. Plants produce sophisticated small molecules that play key roles in defense against predators and environmental elements. These natural products are synthesized through specialized metabolic pathways, […]
Name: Dominick Guida Title: Characterizing and Modeling Heterogeneity in Alkaline Zn-MnO2 Batteries Using Synchrotron CT and EDXRD Date: 11/25/2024 Time: 11:00:00 AM Committee Members: Prof. Joshua Gallaway (Advisor) Prof. Leila Deravi Prof. Richard West Location: EXP 610 and Teams Abstract: Alkaline Zn-MnO2 cells have dominated the primary battery industry for decades, enabled by their inherent […]
Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies Location: 305 Shillman Hall Abstract: Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies Therapeutic immune cells have the potential to treat complex diseases. Some therapies, such as CAR T cells, are effective against blood cancers but are not effective against solid cancers, which comprise about 90% of […]
Name: Peng Zhao Title: Impact of ECM-Based Hydrogel Delivery Vehicle Properties on Cell Survival in a 3D In Vitro Injection Model for Retinal Progenitor Cell Transplantation Date: 12/10/2024 Time: 2:00:00 PM Committee Members: Prof. Rebecca Carrier (Advisor) Prof. Abigail Koppes Prof. Sidi Bencherif Prof. Michael Young Location: EXP 610-A Abstract: Age-related macular degeneration (AMD) is […]
Name: Yuan Li Title: Establishing a Physiologically Relevant Upper Gastrointestinal In Vitro Model Incorporating Bile Salts and Simplified Commensal Microbial Consortium Date: 12/13/2024 Time: 2:00:00 PM Committee Members: Prof. Rebecca Carrier (Advisor) Prof. Abigail Koppes Prof. Erel Levine Prof. Jiahe Li Location: EXP 610-A Abstract: Bacteria-epithelial-immune crosstalk plays crucial roles in intestinal physiology. Bile salts (BS) […]
Developing tools for single-molecule sequencing and imaging of RNA modifications Location: 135 Shillman Hall Abstract: Despite every cell in the human body having the same genetic makeup, gene expression varies greatly between them. The process of DNA transcription into RNA, along with subsequent post-transcriptional modifications, is crucial for achieving this variability and enabling cell specialization. […]
Life in a tight spot: Spying on bacteria in complex spaces Location: 135 Shillman Hall Abstract: Nucleic acids are programmable biomolecules that hold great promises as a therapeutic. However, with over 40 years of development, only a handful of nucleic acid drugs ever reached the market. The lack of greater success is in part due […]
Understanding and mitigating host-part incompatibilities during microbial engineering Location: 135 Shillman Hall Abstract: One of our major goals is to elucidate and highlight the unexpected outcomes that result from modifying living systems and formalize them under the umbrella of “incompatibilities”. For example, when multiple recombinant proteins are co-expressed in bacteria like E. coli, the cellular […]
Investigating the “Black Box” of Active Learning Approaches in Engineering Education Location: 135 Shillman Hall Abstract: In our research on undergraduate engineering education, we seek to build theory about the details of active learning experiences in engineering courses. Engineering educators aspire to support students from all backgrounds and identities in developing deep conceptual understanding and […]
Data-Driven Approaches Towards Controlling the Structure-Property-Processing Relationships of Soft Matter Location: 135 Shillman Hall Abstract: Controlling the hierarchical structure of soft matter, like polymers, from monomer to microstructure to process design is crucial for tailoring their functional properties in advanced materials systems. However, achieving scalable production of advanced soft materials is hindered by their inherent […]