Understanding and mitigating host-part incompatibilities during microbial engineering Location: 135 Shillman Hall Abstract: One of our major goals is to elucidate and highlight the unexpected outcomes that result from modifying living systems and formalize them under the umbrella of “incompatibilities”. For example, when multiple recombinant proteins are co-expressed in bacteria like E. coli, the cellular […]
Life in a tight spot: Spying on bacteria in complex spaces Location: 135 Shillman Hall Abstract: Nucleic acids are programmable biomolecules that hold great promises as a therapeutic. However, with over 40 years of development, only a handful of nucleic acid drugs ever reached the market. The lack of greater success is in part due […]
Developing tools for single-molecule sequencing and imaging of RNA modifications Location: 135 Shillman Hall Abstract: Despite every cell in the human body having the same genetic makeup, gene expression varies greatly between them. The process of DNA transcription into RNA, along with subsequent post-transcriptional modifications, is crucial for achieving this variability and enabling cell specialization. […]