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DTSTART;TZID=America/New_York:20241204T120000
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DTSTAMP:20260417T073140
CREATED:20240806T211609Z
LAST-MODIFIED:20241101T185914Z
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SUMMARY:Chemical Engineering Fall Seminar Series: Omokolade Adebowale
DESCRIPTION:Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies \nLocation: 305 Shillman Hall \nAbstract: Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies Therapeutic immune cells have the potential to treat complex diseases. Some therapies\, such as CAR T cells\, are effective against blood cancers but are not effective against solid cancers\, which comprise about 90% of adult cancers. A key requirement of the role of therapeutic cells in tumor eradication is their ability to migrate to and infiltrate the tumor. To accomplish this\, cells navigate various mechanoimmunological factors\, such as tissue viscoelasticity. One consequence of viscoelasticity is time-dependent stress relaxation – a decrease in stress in response to applied deformation. However\, the mechanisms by which viscoelasticity regulates migration are not fully understood. In addition\, limited studies have quantitatively compared the transport of cell therapies in tissue-like environments. My research aims to address these research gaps. To address the potential role of viscoelasticity on 3D cell migration\, I developed hydrogels that mimic the stress relaxation behavior of native tissues. I found that enhanced stress relaxation potentiates monocyte migration. Mechanistically\, our data support a model whereby WASP-mediated actin polymerization generates physical force at the leading edge of the cell to generate micron-sized channels for cells to migrate through. In a separate project\, I integrated macrophage phenotype and morphometric transitions. Together\, our studies establish a platform to determine the role of mechanical cues in shaping the immune response and to leverage fundamental mechanisms to enable the rational design of “living drugs.” \n\nKolade Adebowale will join the Shu Chien-Gene Lay Department of Bioengineering as an assistant professor in Spring 2025. Dr. Adebowale received his Ph.D. from Stanford University in 2021 under the guidance of Professor Ovijit Chaudhuri. Dr. Adebowale is a postdoctoral fellow with Professor Samir Mitragotri at Harvard University. While at Stanford\, Dr. Adebowale received the NSF GRFP\, a Stanford Graduate Fellowship\, and an NIH F31 grant. At Harvard\, Dr. Adebowale was awarded an NSF Ascend – MPS postdoctoral fellowship and was an NIH MOSAIC K99/R00 scholar. Dr. Adebowale’s main research areas are biomaterials\, mechanobiology\, and immunology. He seeks to integrate engineering design principles in cancer immunology to enable rational engineering and prediction of effective\, next-generation immune cell therapies. Furthermore\, Dr. Adebowale strives to understand how the complex functionality of the immune system arises from mechanical cues and simple biophysical principles. Dr. Adebowale is excited to teach and mentor the next generation of scientists and engineers.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-omokolade-adebowale/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20241106T120000
DTEND;TZID=America/New_York:20241106T130000
DTSTAMP:20260417T073140
CREATED:20240806T211708Z
LAST-MODIFIED:20241101T191234Z
UID:5133-1730894400-1730898000@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Susan Roberts
DESCRIPTION:Molecular Engineering for Production of Anti-cancer Compounds in Plant Cell Culture \nLocation: 305 Shillman Hall \nAbstract: Our research is focused on cellular engineering and design of bioprocesses using plant-based systems. Plants produce sophisticated small molecules that play key roles in defense against predators and environmental elements. These natural products are synthesized through specialized metabolic pathways\, that have both shared and unique components when compared amongst plant systems. These specialized metabolites are useful in a variety of societal applications including as nutraceuticals\, flavorings\, colorings and pharmaceuticals. The supply of these compounds is often hindered due to low yields in nature and the inability to chemically synthesize at scale. We use plant cell culture technology as both a system of study and a scalable production system due to the ability to engineer cells and the environment to optimize accumulation of products of interest. Our group uses a combination of traditional bioprocess engineering techniques (e.g.\, bioreactor design\, cell culture\, media optimization) and modern molecular biology and analytical chemistry techniques (e.g.\, gene transfer\, transcriptomics analyses\, UPLC). Today\, I will focus my talk on molecular engineering strategies to understand and increase paclitaxel production in Taxus plant cell suspension culture. We have applied transcriptomics analyses and genetic engineering tools to understand and manipulate the pathway to paclitaxel\, identify paclitaxel transporters\, and engineer epigenetic mechanisms that can lead to decreased production over time in culture. \n\nDr. Susan Roberts is Professor and Head of Chemical Engineering at WPI. She received her BS degree in Chemical Engineering from WPI in 1992\, PhD in Chemical Engineering from Cornell University in 1998\, served on the faculty at UMass Amherst Chemical Engineering for 17 years and joined WPI as Professor and Head in 2015. Her work has raised over $10M from NSF\, NIH\, industry and government. She is a program builder and has established new interdisciplinary research and education programs through strategic partnerships and external funding from the NSF ADVANCE Program\, NIIMBL Workforce Development Award\, Mass Life Sciences Center\, NSF IGERT and NIH T32 Programs. She is a passionate about faculty development\, training interdisciplinary engineers\, innovating graduate education and advocating for advancement of women and underrepresented groups in STEM fields.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-susan-roberts/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20241016T120000
DTEND;TZID=America/New_York:20241016T130000
DTSTAMP:20260417T073140
CREATED:20240806T211755Z
LAST-MODIFIED:20240826T181712Z
UID:5136-1729080000-1729083600@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Niya Sa
DESCRIPTION:Probe the Dynamic Interfaces of Beyond Lithium-ion Energy Storage Systems \nLocation: 305 Shillman Hall \nAbstract: Rapid growth of technology in the past few decades has spurred a demand for advanced energy storage devices. The invention of a more advanced battery system with higher levels of performance will be a groundbreaking discovery in the rechargeable battery field. Multivalent chemistry offers promising benefits in the development of beyond lithium-ion technologies. The direct usage of the multivalent metal anode is essential to enhance the energy density of the multivalent ion battery. For instance\, Magnesium\, Calcium and Zinc offer an immense alternative to the existing Li-ion batteries due to their multivalent nature and vast abundance in the Earth’s crust. However\, possible film formation at the solid/liquid interface complicates the electrochemical properties of such systems. The least understood solid electrolyte interphase (SEI)\, its formation and dynamic evolution has not been extensively explored for multivalent battery systems with many unknowns remain to be answered. We aim to use electroanalytical tools to probe the dynamic evolution of the solid electrolyte interface in-situ for multivalent systems and investigate its correlation with the electrochemical processes. This presentation focuses on some very recent research findings from our team for understanding the interfacial chemistry\, evolution\, and stability for different multivalent battery systems. \n\nProfessor Niya Sa is an Associate Professor in the Department of Chemistry at the University of Massachusetts Boston. She received her Ph.D. from the Analytical Chemistry (Electroanalytical Chemistry) program at Indiana University-Bloomington\, where she worked with Professor Lane A. Baker on understanding fundamental ion transport phenomena in confined regime. She extended her training working as a postdoc research fellow at the Electrochemical Energy Storage Division at Argonne National Lab. Her research focus at Argonne was to develop beyond lithium-ion battery materials. She joined the University of Massachusetts in 2017 as an Assistant Professor\, and her current research interests include probing the electrochemical interfaces for energy materials\, development of new electrolytes for next-generation energy storage systems. Niya is a recipient of the NSF CAREER Award. She also received the Endowed Faculty Career Development Award\, Joseph P. Healey Award\, and the Early Career Research Excellence Award from University of Massachusetts.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-niya-sa/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20241009T120000
DTEND;TZID=America/New_York:20241009T130000
DTSTAMP:20260417T073140
CREATED:20240806T211835Z
LAST-MODIFIED:20240916T185711Z
UID:5139-1728475200-1728478800@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: William Tisdale
DESCRIPTION:Hybrid Semiconductor Nanomaterials \nLocation: 305 Shillman Hall \nAbstract: Hybrid organic-inorganic semiconductor nanomaterials – including colloidal quantum dots (QDs)\, 2D halide perovskites\, and metal-organic chalcogenolates (MOCs) – are excitonic materials with applications ranging from solar cells to light-emitting devices to quantum computing and quantum cryptography. In these emerging materials\, the combination of quantum and dielectric confinement\, strong exciton-phonon coupling\, and dimensionality reduction offer unprecedented opportunities for controlling light-matter-charge interactions through chemistry. In this talk\, I will describe recent work from my lab on the synthesis of hybrid semiconductor nanomaterials and our evolving understanding of how structure and chemical functionalization influence excited state dynamics. Using a combination of ultrafast laser spectroscopy\, time-resolved optical microscopy\, and kinetic modeling\, we will explore the impact of nonequilibrium population dynamics on excited state transport phenomena and the emergence of unique electronic and vibrational phenomena. \n\nWill Tisdale is the Warren K. Lewis Professor of Chemical Engineering at MIT\, where he has been teaching and leading a research team since 2012. His research program is focused on the discovery of hybrid organic-inorganic nanomaterials capable of transporting energy in new ways\, and on the use and development of ultrafast laser spectroscopy methods and advanced optical microscopy techniques for probing dynamics at the nanoscale. Will’s contributions to research have been recognized by the Presidential Early Career Award for Scientists and Engineers (PECASE)\, an Alfred P. Sloan Fellowship\, the Camille Dreyfus Teacher-Scholar Award\, the DOE Early Career Award\, the NSF CAREER Award\, the AIChE NSEF Young Investigator Award\, and a 3M Non-Tenured Faculty Award. \nFor his dedication to undergraduate teaching Will has received MIT’s highest honor\, the MacVicar Fellowship\, as well as the student-selected Baker Award\, the School of Engineering’s Amare Bose Award\, and he is a 7-time recipient of the C. Michael Mohr Undergraduate Teaching Award\, which is voted annually by the Chemical Engineering undergraduate students at MIT. Will graduated magna cum laude from the University of Delaware in 2005\, earning an Honors B.S. in Chemical Engineering\, with Distinction\, and minoring in Economics. He earned a Ph.D. in Chemical Engineering at the University of Minnesota in 2010\, then studied as a postdoctoral associate in the Research Laboratory of Electronics at MIT before joining the faculty in Chemical Engineering in 2012. \n 
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-william-tisdale/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20241002T120000
DTEND;TZID=America/New_York:20241002T130000
DTSTAMP:20260417T073140
CREATED:20240717T231924Z
LAST-MODIFIED:20240916T174446Z
UID:5010-1727870400-1727874000@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Sujit Datta
DESCRIPTION:Life in a tight spot: Spying on bacteria in complex spaces \nLocation: Snell Engineering Center 168 \nAbstract: Bacteria are arguably the simplest form of life; and yet\, as multi-cellular collectives\, they perform complex functions critical to environment\, food\, health\, and industry. What principles govern how complex behaviors emerge in bacterial collectives? And how can we harness them to control bacterial behavior? In this talk\, I will describe my group’s work addressing this question using tools from soft matter engineering\, 3D imaging\, and biophysical modeling. We have developed the ability to (i) directly visualize bacteria from the scale of a single cell to that of an entire multi-cellular collective\, (ii) 3D-print precisely structured collectives\, and (iii) model their large-scale motion and growth in complex environments. I will describe how\, using this approach\, we are developing new ways to predict and control how bacterial collectives — and potentially other forms of “active matter” — spread large distances\, adapt shape to resist perturbations\, and self-regulate growth to access more space by processing chemical information in their local environments. \n\nSujit Datta is a Professor of Chemical Engineering\, Bioengineering\, and Biophysics at Caltech. Prior\, he was at Princeton University\, where he started his faculty career in 2017 and was promoted to Associate Professor of Chemical and Biological Engineering in 2022. \nSujit earned a BA in Mathematics and Physics and an MS in Physics in 2008 from the University of Pennsylvania\, and then a PhD in Physics in 2013 from Harvard\, where he studied fluid dynamics and instabilities in soft and disordered media with Dave Weitz. His postdoctoral training was in Chemical Engineering at Caltech\, where he studied the biophysics of the gut with Rustem Ismagilov. \nThe Datta Lab studies the dynamics\, self-organization\, and applications of complex\, soft (“squishy”)\, and living systems\, with a focus on complex fluids\, gels\, and bacterial communities/active matter\, motivated by challenges in biotechnology\, energy\, environment\, and medicine. Their work integrates microscopy\, microfluidics\, materials science\, and biophysical characterization with theoretical & computational modeling\, applying ideas from fluid and solid mechanics\, colloidal science\, polymer physics\, statistical mechanics\, and network science. Altogether\, this research program has revealed and shed new light on the fascinating behaviors manifested by complex fluids and bacterial populations in complex environments\, guiding the development of new approaches to environmental remediation\, energy production\, agriculture\, water security\, and biotechnology. \nSujit’s scholarship has been recognized by awards from a broad range of different communities\, reflecting its multidisciplinary nature\, including through the AIChE Allan P. Colburn and 35 Under 35 Awards\, three awards from the APS (Early Career Award in Biological Physics\, Andreas Acrivos Award in Fluid Dynamics\, and Apker Award)\, Pew Biomedical Scholar Award\, Society of Rheology Arthur Metzner Award\, ACS Unilever Award\, Camille Dreyfus Teacher-Scholar Award\, NSF CAREER Award\, and multiple commendations for teaching. In addition to leading professional activities for a number of scientific societies and agencies\, Sujit serves on the editorial boards of Annual Reviews of Condensed Matter Physics and the Journal of Non-Newtonian Fluid Mechanics.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-sujit-datta/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20240925T120000
DTEND;TZID=America/New_York:20240925T130000
DTSTAMP:20260417T073140
CREATED:20240717T231837Z
LAST-MODIFIED:20240828T212208Z
UID:5004-1727265600-1727269200@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Matthew J. Eckleman
DESCRIPTION:Sustainability in the Chemicals Sector: From Green Synthesis to Global Systems\nLocation: 305 Shillman Hall \nAbstract: The chemicals sector is undergoing a transformation driven by decarbonization\, shifting feedstocks\, circularity\, and increasing demand for low-carbon\, non-toxic products. Globally\, chemicals production is responsible for approximately 5% of worldwide greenhouse gas emissions\, stemming from fuel combustion\, process emissions\, and product use. A wide variety of new technologies are being proposed to decarbonize chemicals manufacturing\, but in many cases their environmental benefits are not obvious and they could even have the potential to degrade other aspects of environmental quality. Robust environmental assessment of energy use\, resource inputs\, and emissions over the entire chemicals life cycle is essential for to ensure that proposed green technologies will actually deliver promised environmental benefits. \nTo aid in this\, life cycle assessment (LCA)\, techno-economic analysis (TEA)\, and related tools are increasingly being used in regulation\, certification\, and corporate decision-making. For example\, US biofuels must meet a life cycle greenhouse gas emissions reduction target to be qualified as a renewable fuel\, including emissions from production of chemical inputs that can drive overall results. \nThis seminar will present several LCA-based sustainability modeling projects in the chemicals industry\, from single green syntheses to analysis of technology at the global systems scale. Case studies will include bio-based feedstocks\, decarbonization efforts in pharmaceuticals and medicines\, low-carbon fuels\, and electrochemical synthesis techniques. \n\nMatthew Eckelman is an Associate Professor of civil and environmental engineering and affiliated faculty in chemical engineering at Northeastern\, and adjunct Associate Professor at Yale School of Public Health. His research focuses on process simulation and life cycle assessment for industrial manufacturing\, including primary metals\, commodity and fine chemicals\, pharmaceuticals\, bio- and nano-materials. Dr. Eckelman worked previously for the Massachusetts executive office of environmental affairs and consults regularly on sustainability-related projects for industrial companies and non-profit institutions. He was awarded an NSF CAREER award in environmental sustainability in 2015 and is a member of the Lancet Countdown on Health and Climate Change. He holds a PhD in Chemical and Environmental Engineering from Yale\, where he was affiliated with the Center for Industrial Ecology and the Center for Green Chemistry and Engineering.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-matthew-j-eckleman/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
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