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X-WR-CALDESC:Events for Department of Chemical Engineering
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DTSTART;TZID=America/New_York:20201013T080000
DTEND;TZID=America/New_York:20201013T170000
DTSTAMP:20260426T162744
CREATED:20201014T004855Z
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UID:3386-1602576000-1602608400@che.northeastern.edu
SUMMARY:ChE Seminar Series Presents: Joshua Gallaway
DESCRIPTION:Joshua Gallaway\, Ph.D. \nDiPietro Assistant Professor \nDepartment of Chemical Engineering\, Northeastern University\, Boston\, MA \n“Next Generation for the Grid”  \nAbstract: In our lab\, we study mechanisms within complex electrochemical systems. Practical electrochemical systems such as batteries\, sensors\, and fuel cells are often complex\, involving engineered high surface area electrodes\, starved electrolyte conditions\, phase transformations\, and interplay of the two electrodes. For these reasons\, there are significant deviations from ideal behavior as well as emergent or unexpected phenomena. We seek to understand these to engineer better devices for broad societal benefit\, such as the worldwide adoption of sustainable energy. We have developed strategies for coupling electrochemical methods with materials synthesis\, theory\, and operando analysis techniques\, often based on high energy X-rays. This allows distributed and localized phenomena to be observed within operating electrochemical cells\, and fundamental mechanistic information to be extracted from within the complex system. Thus we have a laboratory equipped for modern electroanalytical study and also make use of specialized X-ray sources maintained by the US Department of Energy. Recent research has focused on low-cost and safe battery materials for electrical storage at the scale of the power grid. Intermittent renewables like solar and wind power will succeed if excess electricity can be stored safely without adding significantly to the cost. \nBiography: Joshua Gallaway has been an Assistant Professor at Northeastern University since 2017\, where he has founded the Analysis of Complex Electrochemical Systems Laboratory (ACES). He received his PhD in chemical engineering from Columbia University in 2007. Working with his advisor Prof. Scott Calabrese Barton\, he characterized the electron transfer rates of enzymes embedded in oxygen-reducing hydrogels. After his PhD work he completed a postdoctoral appointment with Prof. Alan West\, also at Columbia\, studying non-uniform current distributions in sub-micron interconnect features for the semiconductor industry. He then joined the newly-formed CUNY Energy Institute in a research position funded by the Wallis Foundation. There he worked on an ARPA-E funded project headed by Distinguished Professor Sanjoy Banerjee\, which resulted in the spin out company Urban Electric Power. His recent research has focused on using high energy synchrotron techniques to visualize non-uniform reactions within battery electrodes. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-series-presents-joshua-gallaway/
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DTSTART;TZID=America/New_York:20201007T123000
DTEND;TZID=America/New_York:20201007T130000
DTSTAMP:20260426T162744
CREATED:20201005T191425Z
LAST-MODIFIED:20201005T191523Z
UID:3340-1602073800-1602075600@che.northeastern.edu
SUMMARY:ChE Seminar Series Presents: “Engineering Bacteria to Solve Problems in Renewable Chemical Production and Human Health”
DESCRIPTION:ChE Seminar Series Presents:\n \nBenjamin M. Woolston\, PhD \nAssistant Professor\, Department of Chemical Engineering\, Northeastern University\, Boston \, MA \n“Engineering Bacteria to Solve Problems in Renewable Chemical Production and Human Health” \nAbstract: The synthetic biology revolution has given us the ability to genetically reprogram microbes to serve a wide variety of purposes – from miniscule chemical factories that orchestrate exquisitely selective enzymatic pathways to produce fuels\, pharmaceuticals and polymers from simple raw materials – to biological computers that can sense their chemical environment and implement complex decision-making algorithms. The overall goal of the Woolston lab is to harness this potential for applications in renewable energy production and the human gut microbiota. In this talk\, I will present an overview of the two major current thrusts of the lab: In the first\, we are engineering anaerobic bacteria for the conversion of renewable single-carbon feedstocks to biofuels\, taking advantage of a number of economic and ethical benefits of using these substrates compared to 1st and 2nd generation biofuel efforts. In the second\, we are developing engineered microbes that can sense and correct an overabundance of the microbially derived metabolite hydrogen sulfide in the human gut; a toxic\, volatile molecule implicated in the onset of IBD and colorectal cancer. As well as the exciting applied potential of the resultant technology\, these efforts will also provide us with model systems with which to answer broader fundamental questions about microbial metabolism. \nBiography: Dr. Woolston joined the NEU Chemical Engineering department as an Assistant Professor in January 2020. As an NSF Graduate Research Fellow\, Dr. Woolston received his PhD in Chemical Engineering in 2017 from MIT under the guidance of Prof. Greg Stephanopoulos\, where his research focused on the development of genetic tools to enable metabolic engineering in anaerobic CO2-fixing microbes\, and the establishment of a methanol utilization pathway in the model organism Escherichia coli. While at MIT\, he was an inaugural Fellow of the Chemical Engineering Communication Lab\, where he provided peer tutoring and department-wide workshops to assist students and post-docs with aspects of scientific communication. His Post-doctoral work was conducted in the laboratory of Prof. Emily Balskus in the Chemistry & Chemical Biology department at Harvard University\, where he studied microbial metabolic pathways and enzymes that contribute to the stability of health-associated Lactobacilli in the human vaginal microbiota. At Northeastern\, his research program combines approaches from his previous research training in metabolic engineering\, synthetic biology\, biochemistry and microbiology to engineer microbes for biofuel & biochemical production\, and as diagnostics and therapeutics in the Human gut microbiota. His lab team currently consists of three graduate students and two undergraduates. Since joining NEU\, Dr. Woolston has taught the Biochemical Engineering senior elective (CHME 5630) and the graduate course in Kinetics & Reactor Design (CHME 7340). \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-series-presents-engineering-bacteria-to-solve-problems-in-renewable-chemical-production-and-human-health/
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DTSTART;TZID=America/New_York:20201007T120000
DTEND;TZID=America/New_York:20201007T123000
DTSTAMP:20260426T162744
CREATED:20201005T191209Z
LAST-MODIFIED:20201005T191209Z
UID:3339-1602072000-1602073800@che.northeastern.edu
SUMMARY:ChE Seminar Series Presents: “Engineering the intestinal and retinal microenvironments”
DESCRIPTION:ChE Seminar Series Presents:\n \nRebecca Carrier\, Ph.D. \nProfessor & Associate Chair of Research\, Department of Chemical Engineering \nAffiliated Faculty\, Bioengineering\, Northeastern University\, Boston\, MA \n“Engineering the intestinal and retinal microenvironments” \nAbstract: The Advanced Drug Delivery Lab conducts research in regenerative medicine\, with a focus on intestinal and retinal tissue engineering\, and in oral drug delivery\, with a focus on enabling effective oral delivery of therapeutics. In the area of enabling effective oral drug delivery\, we have developed an experimental and theoretical framework to predict the impact of ingested lipids\, in food or drug delivery systems\, on oral drug absorption. This work could have a significant impact on societal health by providing practical\, relevant guidance for the oral dosing of drugs and nutritive supplements. As part of our efforts in enabling effective oral treatments\, we have explored the barrier properties of the gastrointestinal mucus barrier\, and revealed changes in the mucus barrier certain disease states. The lab is now exploring how to alter mucus barrier properties to potentially prevent certain diseases\, including necrotizing enterocolitis. In the area of intestinal tissue engineering\, we are developing human in vitro models of the microbiome-gut-immune axis for understanding the impact of what we ingest and the microbiome on human health. We are also developing biomaterial cell carriers for cell-therapy based retinal regeneration strategies\, with a focus on engineering cues into biomaterial carriers that will promote the survival and integration of implanted cells. \nBiosketch: Rebecca Carrier is a Professor in the Department of Chemical Engineering at Northeastern. She earned a BS in Chemical Engineering from Rensselaer Polytechnic Institute in 1995\, and a Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology in 2000\, where she worked as a pioneer in cardiac muscle tissue engineering. After completing her graduate studies\, Rebecca worked at Pfizer\, Inc.\, as a Senior Research Scientist in oral controlled release drug delivery. She joined Northeastern in 2003\, and the overall theme of her research interests is the interaction between biological systems and materials\, with specific applications in drug delivery and regenerative medicine. She has worked with multiple industrial partners including Pfizer\, Merck\, and Boehringer Ingelheim\, and has received honors including the NSF CAREER award\, NU “Outstanding Teacher (2011)\,” “Faculty Fellow (2014)\,” and Soren Buus Outstanding Research (2017) Awards for excellence in teaching and research leadership. She was also invited to participate in the National Academy of Engineering Frontiers of Engineering (2016) and Frontiers of Engineering Education (2013) Symposia\, served as the Member-At-Large for the Society for Biomaterials from 2018-2019\, and was inducted into the American Institute for Medical and Biological Engineering in 2019. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-series-presents-engineering-the-intestinal-and-retinal-microenvironments/
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DTSTART;TZID=America/New_York:20200930T123000
DTEND;TZID=America/New_York:20200930T130000
DTSTAMP:20260426T162744
CREATED:20200926T001515Z
LAST-MODIFIED:20200926T001515Z
UID:3322-1601469000-1601470800@che.northeastern.edu
SUMMARY:ChE Seminar: "Engineering Innervated Organ Systems"
DESCRIPTION:ChE Seminar Series Presents:   \nRyan Koppes\, Ph.D. \nAssistant Professor\, Department of Chemical Engineering\, Northeastern University\, Boston\, MA \n“Engineering Innervated Organ Systems” \nAbstract:   \nMicrophysiological systems (MPS) hold the potential to provide benchtop models to investigate fundamental biology and disease while reducing the need for animal models. However\, many conventional in vitro models fail to fully capture the complex cell-cell interactions\, 3D microenvironments\, structural organization\, or vascularization of multicellular organ systems. A key criterion for replicating physiologically relevant architectures in a dish is the ability to compartmentalize discrete cell populations\, extracellular matrix compositions\, and/or mechanical properties\, without meaningfully restricting auto- and paracrine signaling. Traditionally\, compartmentalization within MPS has relied on the use of posts or microtunnels fabricated in silicon-based materials\, often requiring expensive lithographic capabilities. Further\, these methods are commonly limited to confining discrete tissues in the x-y plane. Towards overcoming these limitations\, we have developed a new ‘cut & assemble’ manufacturing technique. We have utilized these new tools to establish a number of MPS platforms to model the cardiovascular system. As part of this talk\, I will highlight the potential of this new technology and how we have applied it to model the heart and the adrenal medulla at the benchtop. Further\, through our work\, I will demonstrate how important the inclusion of neuron populations are for recapitulating organ function. \nBiography: \nDr. Ryan Koppes has been an Assistant Professor at Northeastern University since 2015\, where he has founded the Laboratory for Neuromodulation and Neuromuscular Repair (LNNR). Ryan received his Ph.D. in Biomedical Engineering from Rensselaer Polytechnic Institute (RPI) in Troy\, New York in 2013. His doctoral research with Dr. David Corr focused on soft musculoskeletal biomechanics and tissue engineering. In 2013\, Dr. Koppes joined the Bioelectronics Laboratory with Dr. Polina Anikeeva in Material Science and Engineering at MIT\, where he worked as a Translational Fellow on neural interface technology utilizing a multimaterial thermal drawing process and optogenetics. He was the recipient of the NIH R21 Trailblazer in 2017\, is a co-investigator on a 2019 AHA Innovative Project Award\, an NSF I-Corps\, and is a co-investigator on a 2020 NIH BRAIN Initiative R01 between Northeastern\, UCLA\, and Boston Children’s Hospital. Dr. Koppes also enjoys teaching Chemical Engineering Experimental Design Lab II (Unit Operations II) for senior engineers\, as well as mentoring undergraduates in the laboratory. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-engineering-innervated-organ-systems/
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DTSTART;TZID=America/New_York:20200930T120000
DTEND;TZID=America/New_York:20200930T123000
DTSTAMP:20260426T162744
CREATED:20200926T001242Z
LAST-MODIFIED:20200926T001242Z
UID:3321-1601467200-1601469000@che.northeastern.edu
SUMMARY:ChE Seminar: "Engineering the Production of Medicinal Natural Products from Plant Cell Cultures"
DESCRIPTION:ChE Seminar Series Presents:\n \nCarolyn W.T. Lee-Parsons\, Ph.D. \nAssociate Professor\, Chemical Engineering Department; Chemistry & Chemical Biology Department\, Northeastern University\, Boston\, MA \n“Engineering the Production of Medicinal Natural Products from Plant Cell Cultures” \nAbstract: \nMany plant-derived pharmaceuticals are currently supplied by extracting the plant material.  Due to the slow growth rates or low product concentrations in plants\, finding an alternative route for supplying these critical drugs is necessary.  The overall vision of this research is to enhance the production of critical plant-derived pharmaceutical compounds through genetically engineered plant cell cultures\, specifically using the production of terpenoid indole alkaloids (TIAs) from cultures of Catharanthus roseus as a model system.  The C. roseus plant produces several highly valued pharmaceuticals\, including the anti-cancer drugs vincristine and vinblastine.  The high cost and need for these pharmaceuticals motivate our research to better understand their biosynthesis and ultimately overproduce these compounds using C. roseus cultures.  In this talk\, I will present our research in exploring how TIA biosynthesis is regulated and how this knowledge leads to developing synthetic biology strategies for manipulating TIA production. \nBiography: \nCarolyn W.T. Lee-Parsons is an Associate Professor jointly appointed in the Departments of Chemical Engineering and of Chemistry and Chemical Biology at Northeastern University.  She earned her B.S. from the University of Kansas and her Ph.D. from Cornell University\, both in Chemical Engineering.  As an undergraduate\, she modeled reaction networks with Prof. Bala Subramaniam and investigated oil and gas recovery strategies at ARCO Oil and Gas. Growing up in the midst of wheat fields in Kansas\, she was always intrigued by plants and specifically medicines from plants.  As a doctoral student\, she investigated bioprocess strategies for increasing the production of medicines from plant cell cultures with Prof. Michael L. Shuler. \nHer current research area is in plant metabolic engineering and plant synthetic biology.  Her team of graduate and undergraduate students focus on understanding how plants regulate the production of specialized metabolites and on developing and applying tools for engineering the production of pharmaceutical compounds and biofuels from plant tissue cultures and microalgae cultures.  Carolyn seeks to engage majors across disciplines in understanding the fundamentals underlying life in living organisms and translating this understanding to developing solutions to society’s grand challenges.  She contributed to the revision of the widely used textbook for bioprocess engineering (Bioprocess Engineering:  Basic Concepts by M.L. Shuler\, F. Kargi\, and M. DeLisa).  For her teaching and research mentoring\, she was awarded the Martin Essigmann Outstanding Teaching Award and the University Excellence in Teaching Award at Northeastern University. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-engineering-the-production-of-medicinal-natural-products-from-plant-cell-cultures/
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DTSTART;TZID=America/New_York:20200219T114500
DTEND;TZID=America/New_York:20200219T132500
DTSTAMP:20260426T162744
CREATED:20200131T212457Z
LAST-MODIFIED:20200207T005502Z
UID:3080-1582112700-1582118700@che.northeastern.edu
SUMMARY:Engineers Week: Photochemistry as a Tool for imaging\, Priming and Therapy
DESCRIPTION:Dr. Tayyaba Hasan\, Professor\, Harvard Medical School Health Sciences & Technology\, Harvard-MIT \n236 Richards Hall \nOptically Activated Nanomedicines: Photochemistry as a Tool for imaging\, Priming and Therapy \nTayyaba Hasan\, PhD \nWellman Center for Photomedicine\, Massachusetts General Hospital and Harvard Medical School\, Boston\, MA 02114\, USA; Division of Health Sciences and Technology\, Harvard University and Massachusetts Institute of Technology\, Cambridge\, MA 02139\, USA \nOptical activation of materials leads to thermal\, photochemical and radiative processes which can be captured for response-based therapeutic design. The ability to use light as a reagent to control drug release further allows for the fabrication of light controllable intelligent multiagent constructs that attack multiple pathways making the nanomedicines more effective against cancer. Combination therapy is a fairly well accepted standard for cancer treatment and management of other diseases. Typically\, these are administered separately with their own pharmacokinetics\, hitting targets at different times which reduces the synergism potential. Nanomedicines\, to some extent can overcome this limitation by delivering the multiple agents to the target site at the same time provided there is synergism in any aspect of the agents. Photodynamic therapy (PDT) is a photochemistry-based process that is approved for several clinical applications world-wide. It involves the exposure of light activatable molecules to appropriate wavelengths that leads to the generation of active molecular species that is responsible for targeted death. There are many unique attributes to this process. Because of the requirement of light and the photosensitizer being present at the same place at the same time there is an additional level of selectivity. Neither light alone nor the photosensitizer have an effect on target cells by themselves. In addition to the direct cytotoxic effect\, the photodynamic activation primes the microenvironment in a process call PhotoDynamic Priming (PDP) to enable a more potent response to conventional treatments so the PDP becomes an enabler of other treatments\, particularly when administered in a Nanoplatform. Strategies for syntheses and applications in biology and medicine will be discussed. \n\nBio: Tayyaba Hasan\, Ph.D.\, is a Professor of Dermatology at Harvard Medical School and is a Professor at the Harvard-MIT Division of Health Sciences and Technology. She is a leader in photochemical approaches to treatment and diagnosis using targeted strategies and incorporating nanotechnology. She is an inventor of the FDA approved photodynamic treatment of the leading cause of blindness in the western world\, Age-Related Macular Degeneration used in millions of treatments. Her impact on Global Health includes two of her inventions of simple\, smart phone-based\, low-cost devices\, which are being evaluated in clinical studies for treatment of oral cancer and antibiotic identification\, in India and Thailand respectively. In recognition of her translational work and innovations she was the recipient of the NIH’s Pioneer Award in Biomedical Optics\, Bench to Bedside Translation. She was awarded the Britton Chance Biomedical Optics Award in recognition of trailblazing contributions to the field of Photodynamic Therapy\, clinical translation and leadership to the photonics community. She has received four Lifetime Achievement awards from leading scientific organizations including the International Photodynamic Association. She has approximately 300 publications and has 12 US issued patents. She leads 2 multicenter international NCI funded programs for developing and translating innovative treatments of oral\, pancreatic and skin cancers. \nHosted by Chemical Engineering
URL:https://che.northeastern.edu/event/engineers-week-photochemistry-as-a-tool-for-imaging-priming-and-therapy/
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