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DTSTART;TZID=America/New_York:20250910T120000
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DTSTAMP:20260429T135449
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SUMMARY:Chemical Engineering Spring Seminar Series: Francisco Hung
DESCRIPTION:Molecular simulation of interfacial systems: From mechanical properties of liposomes to crystal nucleation in the bulk\, near surfaces and in confinement \nLocation: 108 Snell Engineering Center \nAbstract: I will give an overview of our recent molecular simulation studies of several interfacial systems of interest. In the first part of my talk\, I will describe our classical molecular dynamics (MD) simulations we used to investigate the mechanical properties of liposomes. These nanoparticles made of lipids are important in drug delivery due to their biocompatibility and ability to bolster drug stability\, amplify solubility and facilitate controlled release. While the effects of liposome size\, shape and surface chemistry on drug delivery applications have been widely studied\, liposome mechanical properties such as elasticity and rigidity remain significantly underexplored. Results from the Auguste group in our department suggest that liposome elasticity can be optimally tuned to enhance their performance in drug delivery applications. Our collaborative experimental and simulation studies aim at fundamentally understanding how the mechanical properties of the liposomes are affected by the molecular structure of the lipids\, the composition of the liposome\, and the presence of embedded hydrophobic drugs. In the second part of my talk\, I will describe MD simulations performed in collaboration with the Santiso group at North Carolina State University\, which aimed at fundamentally understanding the nucleation of crystals of ionic liquids (ILs) in the bulk and near carbon surfaces. Solidification of ILs is relevant to the synthesis of IL-based nanomaterials with desired optical and magnetic properties. In more recent collaborative efforts\, we will develop computational methods to study crystallization of a mixture of organic molecules in a solvent confined inside nanopores\, which can be used as a strategy to obtain crystals with a desired structure. Understanding how confinement in nm-sized pores affects crystal nucleation of solutes in solution will enable unprecedented control of crystallization processes\, and lead to direct benefits to society in the form of new pharmaceutical drugs and advanced energetic materials for national defense. \n\nFrancisco Hung joined the Department of Chemical Engineering at Northeastern University in Fall 2016\, from his previous position at the Cain Department of Chemical Engineering at Louisiana State University. He has an un-dergraduate degree in Chemical Engineering from Universidad Simón Bolívar in Caracas\, Venezuela\, a PhD in Chemical Engineering from North Carolina State University\, and had a postdoctoral appointment in the Department of Chemical and Biological Engineering at the University of Wisconsin-Madison prior to joining LSU. Honors include the CAREER Award from the National Science Foundation\, the LSU Rainmaker Emerging Scholar in STEM Award\, and the Richard Sioui Award for Excellence in Teaching in Chemical Engineering at Northeastern University.
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-francisco-hung/
LOCATION:108 SN
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DTSTART;TZID=America/New_York:20250917T120000
DTEND;TZID=America/New_York:20250917T130000
DTSTAMP:20260429T135449
CREATED:20250915T180249Z
LAST-MODIFIED:20250915T180414Z
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SUMMARY:Chemical Engineering Fall Seminar Series: Dennis Leung & Tahnee Dening
DESCRIPTION:Small But Large: Transforming Drug Delivery with Nanoparticle Formulations \nLocation: 108 Snell Engineering Center \nAbstract: This seminar will provide an in-depth exploration of drug nanoparticle formulations\, highlighting the principles\, advantages\, and commercial applications of nanotechnology in drug delivery systems. The discovery of resonant acoustic milling as a new technology for the preparation of drug nanoparticles will be presented\, resulting in a highly scalable and translatable process as well as allowing for high-throughput experimentation. The application of resonant acoustic milling results in nanoparticle formulations with improved drug load and enhanced chemical and physical stability\, as well as extending its application to modalities beyond small molecules\, including peptide therapeutics\, and paves the way towards on-demand personalized medicine. Mechanistic insights into the origin of nanoparticle stability are provided through analytical characterization and molecular dynamics simulations. \n\nDr. Dennis Leung is an accomplished scientist with expertise in drug delivery and pharmaceutical sciences\, combining extensive experience in both academia and industry. He earned his PhD in Chemistry from the University of California\, Berkeley\, and currently serves as the Director of the Discovery Pharmaceutics group at Genentech. Over the course of his career\, Dr. Leung has contributed to a di-verse range of research areas\, focusing on leveraging mechanistic insights to develop innovative strategies for overcoming challenges associated with new drug candidates. His work has been instrumental in advancing small molecule and peptide therapies\, with a particular focus on nanoparticle-based drug de-livery systems. Beyond his research achievements\, Dr. Leung is deeply committed to mentoring the next generation of scientists and fostering collaborations that bridge the gap between academia and industry. \n\nTahnee Dening is a Principal Scientist in the Discovery Pharmaceutics group within the Synthetic Molecule Pharmaceutical Sciences Department at Genentech in South San Francisco. She received her PhD from the University of South Australia and completed postdoctoral training at the University of Kansas\, prior to joining Genentech. Her research focuses on development and application of enabling formulations for challenging molecules and novel modalities\, such as peptides\, as well as characterizing and understanding peptide behavior in the gastrointestinal environment.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-dennis-leung-tahnee-dening/
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DTSTART;TZID=America/New_York:20250924T120000
DTEND;TZID=America/New_York:20250924T130000
DTSTAMP:20260429T135449
CREATED:20250915T180617Z
LAST-MODIFIED:20250915T180617Z
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SUMMARY:Chemical Engineering Fall Seminar Series: Elsie Sunderland
DESCRIPTION:Insights into the fate of precursors and novel PFAS using organofluorine mass budgets across diverse media \nLocation: 108 Snell Engineering Center \nAbstract: Per- and polyfluoroalkyl substances (PFAS) are a diverse family of highly fluorinated and persistent anthropogenic chemicals first synthesized in the 1940s that are not known to degrade under natural conditions. They are broadly used in modern commerce and are now detectable in the most remote environments on Earth. Manufacturing and industrial use of PFAS has shifted dramatically since the onset of their widespread production as concerns about human and ecological exposures to legacy PFAS have grown. The result has been abundant production of compounds in recent decades that are unknown/poorly identified because they lack available analytical standards needed to quantify their presence. Resulting major uncertainties about their fate include degradation in the environment and metabolism by organisms\, propensity for bioaccumulation\, and even their definition as part of the PFAS family of chemicals. This presentation will provide an overview of recent work toward developing total organofluorine mass budgets for U.S. human serum and liver samples and exposure media including freshwater fish\, agricultural products\, drinking water\, and consumer products. Results will highlight major classes of compounds identified using targeted and non-targeted mass spectrometry in combination with combustion ion chromatography to characterize extractable organofluorine. Modeling techniques that help interpret these data and better identify and attribute sources of PFAS contamination will be reviewed. These data will be used to discuss the implications for future policy mechanisms and consumer interventions such as water filtration for mitigating future exposures. \n\nProfessor Elsie Sunderland is the Fred Kavli Professor of Environmental Chemistry and Professor of Earth and Planetary Sciences at Harvard University\, where she has been a faculty member since 2010\, and leads the Biogeochemistry of Global Contaminants Research Group. Her research aims to better understand how chemical pollutants interact with natural ecosystems and affect life. Her group quantitatively analyzes the entire exposure pathway for environmental pollutants to identify key processes that have a large influence on their accumulation in living organisms. Prior to joining the Harvard Faculty\, she spent five years at the headquarters for the U.S. Environmental Protection Agency working on regulatory impact assessments and developing guidance on how to best use environmental models to inform regulatory decisions. Over the past 20 years\, she has collaborated extensively with indigenous groups\, NGOs\, and state\, federal and international government organizations. Her work has informed strategies for managing risks associated with environmental chemical exposures from energy infrastructure such as coal-fired power plants and hydroelectric dams\, and global regulatory efforts for mercury and per- and polyfluoroalkyl substances (PFAS). Professor Sunderland has mentored >50 graduate students and postdoctoral fellows. She is the Editor-in-Chief for the Royal Society of Chemistry journal Environmental Science: Processes and Impacts and on the Editorial Advisory Board for the American Chemical Society journal Environmental Science & Technology. Prof. Sunderland received her B.Sc. from McGill University in 1997 and Ph.D. from Simon Fraser University in 2003. Outside of science\, she is interested in dogs (particularly if they have beards)\, running\, being a soccer/sailing mom for her two kids\, and coastal conservation.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-elsie-sunderland/
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