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X-ORIGINAL-URL:https://che.northeastern.edu
X-WR-CALDESC:Events for Department of Chemical Engineering
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DTSTART;TZID=America/New_York:20240911T090000
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DTSTAMP:20260516T194835
CREATED:20240903T175736Z
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UID:5173-1726045200-1726052400@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Ronodeep Mitra
DESCRIPTION:Name:\nRonodeep Mitra \nTitle: \nGlycocalyx Therapy to Restore Anti-Atherosclerotic Endothelial Cell Function \nDate:\n9/11/2024 \nTime:\n9:00:00 AM \nCommittee Members:\nProf. Eno Ebong (Advisor)\nProf. Mansoor Amiji\nProf. Rebecca Carrier\nProf. Arthur J. Coury\nProf. Jessica M. Oakes \nLocation:\nEXP 610 and Zoom \nAbstract:\nThe endothelial cell (EC) glycocalyx (GCX) is a negatively charged complex sugar-rich layer that lines the endothelium. It is an important contributor to the physical and biochemical health of the vasculature and endothelium\, while mediating mechanotransduction and vascular signaling. For example\, when exposed to physiological (unidirectional and uniform in magnitude) levels of shear stress from the mechanical force of blood flow\, the GCX is abundant and aids in the production of vasodilator nitric oxide (NO)\, which regulates vascular tone. Furthermore\, the dynamics of the flow-regulated GCX determine the structural integrity of connexin proteins that comprises interendothelial gap junctions and control the flow of communication between neighboring ECs. Finally\, the GCX acts as a physical barrier to numerous components in circulating blood\, including low-density lipoproteins (LDLs) and inflammatory cells such as monocytes that differentiate into macrophages and platelets. \nLoss of the EC GCX can be attributed to disturbed vasculature blood flow patterns. This condition renders the endothelium as adhesive and permeable\, resulting in infiltration of the vessel walls by blood circulating LDLs\, compromising active EC-EC communication via interendothelial gap junctions\, and reduction in NO production\, leading to vasoconstriction. These phenotypes lead to vascular dysfunction\, atherosclerosis\, and other serious secondary cardiovascular events\, such as myocardial infarctions and strokes. Hence\, we propose either repurposing therapies that were\nnot originally indicated for GCX therapy or the development of novel GCX therapies and hypothesize that targeting the EC GCX will restore vascular function and prevent further downstream cardiovascular events\, such as atherosclerosis. \nWe first tested our hypothesis by assessing the efficacy of repurposing diosmin\, a flavanone glycoside of diosmetin\, which is a nutraceutical used to currently treat chronic venous insufficiency. Previous studies have shown diosmin’s potent anti-inflammatory and anti-oxidant properties on the endothelium. Hence\, we wanted to determine if diosmin would repair mechanically damaged endothelial GCX in regions of disturbed flow (DF) patterns and restore anti-atherosclerotic endothelium mechanotransduction function. For this study\, we utilized a unique murine in vivo DF model\, where the left carotid artery (LCA) is partially ligated\, while the right carotid artery (RCA) is not surgically intervened and was the designated uniform flow (UF) control for each mouse. Diosmin treatment elevated activated endothelial NO synthase level (p-eNOS)\, inhibited inflammatory cell uptake\, decreased vessel wall thickness and increased vessel diameter\, and increased GCX coverage on the endothelium in ligated LCA. This corroborated support that diosmin protects endothelial GCX integrity and preserves complex endothelial function. \nNext\, in vitro and in vivo DF models were used to assess a novel therapy\, combining sphingosine-1-phosphate (S1P)\, a bioactive lipid mediator\, and heparin in regenerating the endothelial GCX. We used a parallel-plate flow chamber to simulate flow conditions in vitro on human coronary arterial endothelial cells (HCAECs) and a partial carotid ligation murine model to mimic DF in vivo\, as mentioned above. In vitro data showed that heparin/S1P therapy improved the function of DF-conditioned ECs by restoring the GCX and promoting EC alignment and elevated p-eNOS expression. Furthermore\, heparin/S1P treatment restored GCX in the LCA\, enhancing GCX thickness and coverage of the blood vessel wall and reducing vessel wall thickness\, demonstrating advances in a novel therapeutic that regenerates EC GCX and restores complex vascular function in DF conditions. \nThis research work is an excellent step towards the development of repurposed or novel therapeutics that can be applied to replace\, stabilize\, or protect the GCX and restore GCX-mediated EC mechanotransduction\, particularly in DF conditions. These prospective mechano-therapeutics could represent breakthrough solutions for preventing cardiovascular diseases such as atherosclerosis in the future.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-ronodeep-mitra/
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DTSTART;TZID=America/New_York:20240917T100000
DTEND;TZID=America/New_York:20240917T143000
DTSTAMP:20260516T194835
CREATED:20240722T220020Z
LAST-MODIFIED:20240722T220020Z
UID:5077-1726567200-1726583400@che.northeastern.edu
SUMMARY:Chemical Engineering Research Showcase
DESCRIPTION:Join us for our Annual Chemical Engineering Research Showcase in the Cabral Center! Every year\, our Chemical Engineering PhD students and select faculty members present their work at the Research Showcase in the form of Oral Presentations\, Poster Sessions\, and 5-minute Presentations. All are welcome to attend.
URL:https://che.northeastern.edu/event/chemical-engineering-research-showcase/
LOCATION:The Cabral Center\, 40 Leon Street\, Boston\, MA\, 02115\, United States
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240917T153000
DTEND;TZID=America/New_York:20240917T173000
DTSTAMP:20260516T194835
CREATED:20240722T220255Z
LAST-MODIFIED:20240722T220255Z
UID:5085-1726587000-1726594200@che.northeastern.edu
SUMMARY:Chemical Engineering Welcome Back Event
DESCRIPTION:Please join the Chemical Engineering Department for our Welcome Back Event in Robinson Quad on September 13th from 3:30-5:30 PM. \nAll Chemical Engineering students\, both new and returning\, undergraduate and graduate\, are invited! \nCome enjoy some great food and get to know your professors and fellow students!
URL:https://che.northeastern.edu/event/chemical-engineering-welcome-back-event/
LOCATION:Robinson Quad Tents\, 360 Huntington Ave\, outside Mugar\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20240925T120000
DTEND;TZID=America/New_York:20240925T130000
DTSTAMP:20260516T194835
CREATED:20240717T231837Z
LAST-MODIFIED:20240828T212208Z
UID:5004-1727265600-1727269200@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Matthew J. Eckleman
DESCRIPTION:Sustainability in the Chemicals Sector: From Green Synthesis to Global Systems\nLocation: 305 Shillman Hall \nAbstract: The chemicals sector is undergoing a transformation driven by decarbonization\, shifting feedstocks\, circularity\, and increasing demand for low-carbon\, non-toxic products. Globally\, chemicals production is responsible for approximately 5% of worldwide greenhouse gas emissions\, stemming from fuel combustion\, process emissions\, and product use. A wide variety of new technologies are being proposed to decarbonize chemicals manufacturing\, but in many cases their environmental benefits are not obvious and they could even have the potential to degrade other aspects of environmental quality. Robust environmental assessment of energy use\, resource inputs\, and emissions over the entire chemicals life cycle is essential for to ensure that proposed green technologies will actually deliver promised environmental benefits. \nTo aid in this\, life cycle assessment (LCA)\, techno-economic analysis (TEA)\, and related tools are increasingly being used in regulation\, certification\, and corporate decision-making. For example\, US biofuels must meet a life cycle greenhouse gas emissions reduction target to be qualified as a renewable fuel\, including emissions from production of chemical inputs that can drive overall results. \nThis seminar will present several LCA-based sustainability modeling projects in the chemicals industry\, from single green syntheses to analysis of technology at the global systems scale. Case studies will include bio-based feedstocks\, decarbonization efforts in pharmaceuticals and medicines\, low-carbon fuels\, and electrochemical synthesis techniques. \n\nMatthew Eckelman is an Associate Professor of civil and environmental engineering and affiliated faculty in chemical engineering at Northeastern\, and adjunct Associate Professor at Yale School of Public Health. His research focuses on process simulation and life cycle assessment for industrial manufacturing\, including primary metals\, commodity and fine chemicals\, pharmaceuticals\, bio- and nano-materials. Dr. Eckelman worked previously for the Massachusetts executive office of environmental affairs and consults regularly on sustainability-related projects for industrial companies and non-profit institutions. He was awarded an NSF CAREER award in environmental sustainability in 2015 and is a member of the Lancet Countdown on Health and Climate Change. He holds a PhD in Chemical and Environmental Engineering from Yale\, where he was affiliated with the Center for Industrial Ecology and the Center for Green Chemistry and Engineering.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-matthew-j-eckleman/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
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