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DTSTART;TZID=America/New_York:20221102T120000
DTEND;TZID=America/New_York:20221102T130000
DTSTAMP:20260425T120933
CREATED:20221019T175830Z
LAST-MODIFIED:20221019T175830Z
UID:4262-1667390400-1667394000@che.northeastern.edu
SUMMARY:Engineered cellular models to explore human disease heterogeneity
DESCRIPTION:ChE Seminar Series Presents:  \nAlison McGuigan\, PhD \nProfessor\, Chemical Engineering & Applied Chemistry\, University of Toronto \nAbstract: \nEx vivo culture models provide powerful tools to interrogate the role of tumour heterogeneity in human cancers. Patient-derived organoids (PDOs) are emerging as powerful models to capture the genetic heterogeneity of human tumors. However\, extrinsic factors present in the tumor microenvironment (TME) of a tumour\, such as the presence of stromal cells and gradients of small molecules such as oxygen\, also affect cancer phenotype and response to therapy. This talk will describe tissue-engineered platforms we have developed 1) to enable controlled assembly and disassembly of organoid structures to study the impact of both genetic and microenvironmental heterogeneity on tumor cell behavior and 2) to explore tumour microenvironment remodelling\, heterogeneity in response to therapy\, and potential to re-grow after therapy. \nBio: \nDr. Alison McGuigan is a Professor in Chemical Engineering and Applied Chemistry and the Institute for Biomedical Engineering at University of Toronto. She obtained her undergraduate degree from University of Oxford\, her PhD from University of Toronto working\, and completed Post Doctoral Fellowships at Harvard University and Stanford School of Medicine. Dr. McGuigan research group is focused on the engineering of tissue models to explore mechanisms of disease and regeneration. Dr. McGuigan has established strategies to generate multi-component tissue systems with specified organization. Furthermore\, she has pioneered the design of tissue platforms for smart data acquisition\, with a focus on stratifying heterogeneous bulk data by cell population\, by spatial location\, or by time. In recognition of Dr. McGuigan’s work she has received numerous awards including the 2013 TERMIS-AM Young Investigator Award\, and the Canadian Society for Chemical Engineering Hatch Innovation Award. In 2018 was elected to the Royal Society of Canada-College of New Scholars\, Artists and Scientists and in 2022 she was elected a Fellow of TERM by the Tissue Engineering and Regenerative Medicine International Society. She serves on the executive leadership team of CFREF Medicine by Design program and on the Centre for Commercialization of Regenerative Medicine (CCRM) incubation and outreach committee.
URL:https://che.northeastern.edu/event/engineered-cellular-models-to-explore-human-disease-heterogeneity/
LOCATION:236 Richards\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20221109T120000
DTEND;TZID=America/New_York:20221109T130000
DTSTAMP:20260425T120933
CREATED:20221019T175325Z
LAST-MODIFIED:20221019T175325Z
UID:4258-1667995200-1667998800@che.northeastern.edu
SUMMARY:Leveraging the Natural Cellular and Biomolecular Interactions in Blood for the Design of Targeted\, Anti-Inflammatory Particle Therapeutics
DESCRIPTION:ChE Seminar Series Presents:  \nDr. Omolola (Lola) Eniola-Adefeso \nAssociate Dean for Graduate and Professional Education in the College of Engineering at the University of Michigan-Ann Arbor \nAbstract:  \nVascular-targeted particle therapeutics offer the possibility of increased drug effectiveness while minimizing side effects often associated with systemic drug administration. Factors that influence the likelihood of targeted particle therapeutics to reach the vascular wall are the ability to identify: 1) a disease-specific target\, 2) the appropriate drug carrier type and geometry for efficient interaction with the vascular wall\, and 3) a drug-carrier combination that allows for the desired release of the targeted therapeutics. Our work focuses on probing the role of particle geometry\, material chemistry\, and blood rheology/dynamics on the ability of vascular-targeted drug carriers to interact with the blood vessel wall – an important consideration that will control the effectiveness of drug targeting regardless of the targeted disease or delivered therapeutically. This presentation will highlight the carrier-blood cell interactions that affect drug carrier binding to the vascular wall and alter critical neutrophil functions in disease. The talk will present the material design parameters for optimal drug carriers’ design for active and passive use in treating acute lung injury and other inflammatory diseases. \nBio: \nDr. Omolola (Lola) Eniola-Adefeso is the University Diversity and Social Transformation Professor of Chemical Engineering and Biomedical Engineering and the Associate Dean for Graduate and Professional Education in the College of Engineering at the University of Michigan-Ann Arbor.  She received a doctoral degree (2004) in Chemical and Biomolecular Engineering at the University of Pennsylvania. She was a postdoctoral associate in the Pediatrics/Leukocyte Biology at Baylor College of Medicine. Dr. Eniola-Adefeso joined the faculty of Chemical Engineering at the University of Michigan in 2006\, where she runs the Cell Adhesion and Drug Delivery Laboratory.   Since she arrived at Michigan\, Dr. Eniola-Adefeso has received several honors and awards\, including the NSF CAREER Award\, American Heart Association Innovator Award\, and most recently\, the BMES MIDCAREER Award. She is a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society and serves as Deputy Editor for Science Advances. Her research is currently funded by multiple grants from the NIH NHLBI\, American Heart Association\, and the National Science Foundation. \n 
URL:https://che.northeastern.edu/event/leveraging-the-natural-cellular-and-biomolecular-interactions-in-blood-for-the-design-of-targeted-anti-inflammatory-particle-therapeutics/
LOCATION:236 Richards\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
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