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DTSTART;TZID=America/New_York:20210407T120000
DTEND;TZID=America/New_York:20210407T130000
DTSTAMP:20260414T051943
CREATED:20210405T174754Z
LAST-MODIFIED:20210405T174754Z
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SUMMARY:ChE Seminar Series: Engineered Autonomous Control of Metabolic Pathways
DESCRIPTION:ChE Seminar Series Presents: \nKristala L. J. Prather\, Ph.D.\nArthur D. Little Professor\, Department Executive Officer\, Department of Chemical Engineering\, MIT \nEngineered Autonomous Control of Metabolic Pathways \nAbstract\nMicrobial systems offer the opportunity to produce a wide variety of chemical compounds in a sustainable fashion. Economical production\, however\, requires processes that operate with high titer\, productivity\, and yield. One challenge towards maximizing yields is the need to use substrate for biomass\, resulting in a competing pathway that cannot merely be eliminated. Productivities may also be significantly influenced by the timing of expression of genes in the production pathway. Dynamic metabolic engineering has emerged as a means to address these and other impediments in strain performance. Ideally\, the triggers for dynamic control would be autonomous\, that is\, independent of any external intervention by the operator. We have developed such autonomous devices based on pathway-independent quorum-sensing circuits and have demonstrated their utility across several distinct metabolic pathways and with varying levels of complexity. In this talk\, I will describe our approach for development of these Metabolite Valves and results to date from their implementation. \nBiography\nKristala L.J. Prather is the Arthur D. Little Professor in and Executive Officer of the Department of Chemical\nEngineering at MIT. She received an S.B. degree from MIT in 1994 and Ph.D. from the University of California\, Berkeley (1999)\, and worked 4 years in BioProcess Research and Development at the Merck Research Labs prior to joining MIT. Her research interests are centered on the design and assembly of recombinant microorganisms for the production of small molecules\, with additional efforts in novel bioprocess design approaches. A particular focus is the elucidation of design principles for the production of unnatural organic compounds with engineered control of metabolic flux within the framework of the burgeoning field of synthetic biology. Prather is the recipient of an Office of Naval Research Young Investigator Award (2005)\, a Technology Review “TR35” Young Innovator Award (2007)\, a National Science Foundation CAREER Award (2010)\, the Biochemical Engineering Journal Young Investigator Award (2011)\, and the Charles Thom Award of the Society for Industrial Microbiology and Biotechnology (2017). Additional honors include selection as the Van Ness Lecturer at Rensselaer Polytechnic Institute (2012)\, as a Fellow of the Radcliffe Institute for Advanced Study (2014-2015)\, the American Association for the Advancement of Science (AAAS; 2018)\, and the American Institute for Medical and Biological Engineering (AIMBE; 2020). \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-series-engineered-autonomous-control-of-metabolic-pathways/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210409T120000
DTEND;TZID=America/New_York:20210409T130000
DTSTAMP:20260414T051943
CREATED:20210405T174852Z
LAST-MODIFIED:20210405T174852Z
UID:3544-1617969600-1617973200@che.northeastern.edu
SUMMARY:ChE Seminar Series: Tools for Analyzing and Repairing Biological Systems
DESCRIPTION:ChE Seminar Series Presents: \nDr. Edward S. Boyden\, Ph. D.\nY. Eva Tan Professor in Neurotechnology at MIT\nHoward Hughes Medical Institute\, McGovern Institute\nProfessor\, Departments of Brain and Cognitive Sciences\, Media Arts and Sciences\, and Biological Engineering\, MIT \nTools for Analyzing and Repairing Biological Systems \nAbstract \nUnderstanding and repairing complex biological systems\, such as the brain\, requires technologies for systematically observing and controlling these systems.  We are discovering new molecular principles that enable such technologies.  For example\, we discovered that one can physically magnify biological specimens by synthesizing dense networks of swellable polymer throughout them\, and then chemically processing the specimens to isotropically swell them.  This method\, which we call expansion microscopy\, enables ordinary microscopes to do nanoimaging – important for mapping the brain across scales.  Expansion of biomolecules away from each other also decrowds them\, enabling previously invisible nanostructures to be labeled and seen.  As a second example\, we discovered that microbial opsins\, genetically expressed in neurons\, could enable their electrical activities to be precisely controlled in response to light.  These molecules\, now called optogenetic tools\, enable causal assessment of how neurons contribute to behaviors and pathological states\, and are yielding insights into new treatment strategies for brain diseases.  Finally\, we are developing\, using new strategies such as robotic directed evolution\, fluorescent reporters that enable the precision measurement of signals such as voltage and calcium.  By fusing such reporters to self-assembling peptides\, they can be stably clustered within cells at random points\, distant enough to be resolved by a microscope\, but close enough to spatially sample the relevant biology. Such clusters\, which we call signaling reporter islands (SiRIs)\, permit many fluorescent reporters to be used within a single cell\, to simultaneously reveal relationships between different signals.  We share all these tools freely\, and aim to integrate the use of these tools so as to enable comprehensive understandings of neural circuits. \nBiography: \nEd Boyden is Y. Eva Tan Professor in Neurotechnology at MIT\, an investigator of the Howard Hughes Medical Institute and the MIT McGovern Institute\, and professor of Brain and Cognitive Sciences\, Media Arts and Sciences\, and Biological Engineering at MIT. He leads the Synthetic Neurobiology Group\, which develops tools for analyzing and repairing complex biological systems such as the brain\, and applies them systematically to reveal ground truth principles of biological function as well as to repair these systems. He co-directs the MIT Center for Neurobiological Engineering\, which aims to develop new tools to accelerate neuroscience progress\, and is a faculty member of the MIT Center for Environmental Health Sciences\, Computational & Systems Biology Initiative\, and Koch Institute. \nAmongst other recognitions\, he has received the Wilhelm Exner Medal (2020)\, the Croonian Medal (2019)\, the Lennart Nilsson Award (2019)\, the Warren Alpert Foundation Prize (2019)\, the Rumford Prize (2019)\, the Canada Gairdner International Award (2018)\, the Breakthrough Prize in Life Sciences (2016)\, the BBVA Foundation Frontiers of Knowledge Award (2015)\, the Carnegie Prize in Mind and Brain Sciences (2015)\, the Jacob Heskel Gabbay Award (2013)\, the Grete Lundbeck Brain Prize (2013)\, the NIH Director’s Pioneer Award (2013)\, the NIH Director’s Transformative Research Award (three times\, 2012\, 2013\, and 2017)\, and the Perl/UNC Neuroscience Prize (2011). He was also named to the World Economic Forum Young Scientist list (2013) and the Technology Review World’s “Top 35 Innovators under Age 35” list (2006)\, and is an elected member of the National Academy of Sciences (2019)\, the American Academy of Arts and Sciences (2017)\, the National Academy of Inventors (2017)\, and the American Institute for Medical and Biological Engineering (2018). His group has hosted hundreds of visitors to learn how to use new biotechnologies\, and he also regularly teaches at summer courses and workshops in neuroscience\, and delivers lectures to the broader public (e.g.\, TED (2011)\, TED Summit (2016)\, World Economic Forum (2012\, 2013\, 2016)). \nEd received his Ph.D. in neurosciences from Stanford University as a Hertz Fellow\, working in the labs of Jennifer Raymond and Richard Tsien\, where he discovered that the molecular mechanisms used to store a memory are determined by the content to be learned. In parallel to his PhD\, as an independent side project\, he co-invented optogenetic control of neurons\, which is now used throughout neuroscience. Previously\, he studied chemistry at the Texas Academy of Math and Science at the University of North Texas\, starting college at age 14\, where he worked in Paul Braterman’s group on origins of life chemistry. He went on to earn three degrees in electrical engineering and computer science\, and physics\, from MIT\, graduating at age 19\, while working on quantum computing in Neil Gershenfeld’s group. Long-term\, he hopes that understanding how the brain generates the mind will help provide a deeper understanding of the human condition\, and perhaps help humanity achieve a more enlightened state. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-series-tools-for-analyzing-and-repairing-biological-systems/
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DTSTART;TZID=America/New_York:20210416T120000
DTEND;TZID=America/New_York:20210416T130000
DTSTAMP:20260414T051943
CREATED:20210415T192227Z
LAST-MODIFIED:20210415T192227Z
UID:3546-1618574400-1618578000@che.northeastern.edu
SUMMARY:Che Seminar Series: Creating Inclusive Spaces in the Curriculum to Improve the Classroom Climate
DESCRIPTION:ChE Seminar Series Presents: Dr. Matthew Lee \nMatthew Lee\, PhD \nTeaching Professor of Human Services \nNortheastern University \nCreating Inclusive Spaces in the Curriculum to Improve the Classroom Climate \nAbstract: In this Distinguished Lecture\, Professor Matthew Lee\, PhD\, from the Human Services Program at Northeastern\, will discuss his life\, career\, and lifelong commitment to equity and diversity for college students. Drawing on his years of experience engaged in intergroup dialogue\, research\, teaching study abroad\, and anti-racist training\, Dr. Lee will describe some lessons for attendees to consider in developing a more inclusive curriculum and climate. Question & answer period to take place during the session. \nBio: Dr. Matthew Lee received his PhD in Clinical and Community Psychology from the University of Illinois at Urbana-Champaign. He has taught courses in counseling theory and practice\, cross-cultural psychology\, ethnic identity and conflict (in Romania\, Germany\, Poland\, and Croatia)\, intro to psychology\, lifespan development\, developmental psychology\, race and empowerment\, Asian American identity\, psychology and literature\, and senior capstone. \nHis research examines campus climate and advocacy for diversity/inclusion in the classroom\, and Asian American mental health as it relates to experiences of microaggressions that may be associated with phenotype or socialization.
URL:https://che.northeastern.edu/event/che-seminar-series-creating-inclusive-spaces-in-the-curriculum-to-improve-the-classroom-climate/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210421T120000
DTEND;TZID=America/New_York:20210421T130000
DTSTAMP:20260414T051943
CREATED:20210420T180408Z
LAST-MODIFIED:20210420T180408Z
UID:3547-1619006400-1619010000@che.northeastern.edu
SUMMARY:ChE Seminar Series: Biomaterials to unlock the regenerative capacity of tissues
DESCRIPTION:ChE Seminar Series Presets: Dr. Tatiana Segura \nTatiana Segura\, PhD \nProfessor of Biomedical Engineering\, Duke University \nBiomaterials to unlock the regenerative capacity of tissues \nAbstract: Injectable materials that can conform to the shape of a desired space are used in a variety of fields including medicine. The ability to fill a tissue defect with an injectable material can be used for example to deliver drugs\, augment tissue volume\, or promote repair of an injury. This talk will explore the development of injectable materials that are based on assembled particle building blocks\, for tissue repair. We find that using microparticle building blocks to build the scaffold generates a porous network by the space left behind between adjacent building blocks. Due to the injectability of this microporous material we have explored its wide applicability to tissue repair applications ranging from skin to brain wounds. In this talk\, I will describe how MAP scaffolds can modulate the wound healing immune response and lead to regenerative wound healing. \nBiography: Professor Tatiana Segura received her BS degree in Bioengineering from the University of California Berkeley and her doctorate in Chemical Engineering from Northwestern University. Her graduate work in designing and understanding non-viral gene delivery from hydrogel scaffolds was supervised by Prof. Lonnie Shea. She pursued post-doctoral training at the Swiss Federal Institute of Technology\, Lausanne under the guidance of Prof. Jeffrey Hubbell\, where her focus was self-assembled polymer systems for gene and drug delivery. Professor Segura’s Laboratory studies the use of materials for minimally invasive in situ tissue repair. On this topic\, she has published 113 peered reviewed publications to date. She has been recognized with the Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy\, the American Heart Association National Scientist Development Grant\, and the CAREER award from National Science Foundation. She was Elected to the College of Fellows at the American Institute for Medical and Biological Engineers (AIMBE) in 2017. She spent the first 11 years of her career at UCLA department of Chemical and Biomolecular Engineering and has recently relocated to Duke University\, where she holds appointments in Biomedical Engineering\, Neurology and Dermatology.
URL:https://che.northeastern.edu/event/che-seminar-series-biomaterials-to-unlock-the-regenerative-capacity-of-tissues/
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