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DTSTART;TZID=America/New_York:20250609T140000
DTEND;TZID=America/New_York:20250609T160000
DTSTAMP:20260417T053000
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SUMMARY:ChE PhD Dissertation Defense: Matthew Fernez
DESCRIPTION:Name:\nMatthew Fernez \nTitle:\nDevelopment of a Hydrogen Sulfide Biosensor and Interrogation the Role of Sulfide on Mucus Barriers \nDate:\n06/05/2024 \nTime:\n10:00:00 AM \nCommittee Members:\nProf. Benjamin Woolston (Advisor)\nProf. Rebecca Carrier (Co-Advisor)\nProf. Erel Levine\nDr. Jodie Ouahed \nLocation:\nShillman 420 \nAbstract:\nInflammatory bowel disease (IBD) is a gastrointestinal condition that is estimated to afflict more than 1% of adults\, with prevalence increasing over time. Hydrogen sulfide (H2S)\, produced by the gut microbiota and partially by the host epithelium\, has long been associated with IBD through metagenomic evidence of increased populations of sulfate producing bacteria in patients. However\, the effects of sulfide are disputed and the mechanisms underlying disease pathogenesis remain unresolved. Sulfide literature suggests both a therapeutic and restorative effect at low levels yet also implies higher levels may be toxic\, resulting in disruption of mucus barriers and promotion of an inflammatory cascade. The mucus barrier is comprised of a mucin network crosslinked by disulfide bonds\, along with myriad heterogenous components\, which provides protection for the cell lining from the microbiota and toxic byproducts. We hypothesize that in excess\, sulfide reduces disulfide bonds yielding a weaker\, more permeable barrier that is susceptible to microbial penetration. However\, studying sulfide in the gut microenvironment is technically challenging due to its high volatility and reactivity\, making accurate GI measurements challenging in vivo. Here\, we seek to address measurement limitations through the development of a sulfide biosensor and evaluate the impacts of sulfide on mucus barriers. \nThis thesis has three core elements: optimization of a functional sulfide biosensor\, exploration of implementation in a mesofluidic gut-on-chip\, and direct evaluation of sulfide on mucus barrier properties. To construct a transcriptional sulfide biosensor\, a polysulfide sensitive repressor\, SqrR\, from Rhodobacter capsulatus was codon harmonized and inserted into a plasmid with a fluorescent reporter module driven by the SqrR affiliated promoter pSqr. To convert sulfide into polysufides that de-activate SqrR\, we coupled the sensing plasmid with an enzymatic plasmid bearing codon harmonized Sqr from R. capsulatus. Initial construction failed to generate a response to sulfide\, but an 18-fold dynamic range up to 750 M in aerobic conditions was produced through pSqr engineering and SqrR tagging and titration. Sqr activity and products were characterized\, but failed to generate a response under anaerobic conditions likely due to electron transport chain dependent quinone incompatibility. Given that the gut microenvironment is largely anaerobic\, sensor response under anaerobic conditions was recovered through isolation of a novel Sqr homolog from Wolinella succinogenes\, an organism that couples sulfide oxidation to reduction of fumarate\, a compound abundant in the gut. We demonstrate sensor activity under anoxic conditions using this enzyme with both fumarate and nitrate\, a marker of the inflamed gut. The group has previously developed a gut on chip PDMS device with vertical orientation for cross sectional imaging of the mucus barrier of primary intestinal epithelium under static conditions. The gas permeability of PDMS encouraged us to attempt gel wall modifications to permit consistent delivery of sulfide via flow. While modifications of the gut chip to operate under continuous flow culture were unsuccessful\, a simple demonstration of a partial response to sulfide by the biosensor on chip is presented in the absence of epithelium\, illustrating promise for implementation as a diagnostic in the future. Finally\, the impacts of sulfide on mucus were elucidated in the third part of the thesis. Using harvested porcine intestinal mucus (PIM)\, we demonstrate that diffusivity of polystyrene nanoparticles in PIM increases 1.6 fold when treated with 1 mM sulfide. Sulfide also impacted microbial velocity and motion type\, yielding a statistically significant increase of average velocity and proportion of microbes exhibiting penetration like behavior. While structural changes were not observed through lectin staining of PIM\, the thesis culminates in a simple demonstration of deleterious effects of sulfide on a living mucus barrier in our gut on chip system. Mucus thickness was reduced and resulted in an increased proportion of nanoparticles that penetrated the mucus barrier. Taken together\, this work produced a novel sulfide biosensor that functions under aerobic and anaerobic conditions and characterized the deleterious effects of sulfide on barrier permeability suspected by the underlying hypothesis of reduction of disulfide bonds in mucus structure. \n\n \nMatt Fernez is currently a sixth year PhD student in Chemical Engineering at Northeastern University. He completed a Bachelor of Science in Chemical Engineering in May\, 2019 at University of Massachusetts Amherst where he also produced an honors thesis. In June of this year\, he will defend his PhD Thesis to complete the doctoral degree. His research is co-advised and focuses on synthetic biology and tissue engineering\, with the focus of studying mucus barrier properties utilizing genetically engineered bacteria. His dissertation is titled “Development of a Hydrogen Sulfide Biosensor and Interrogation the Role of Sulfide on Mucus Barriers”. He has contributed towards authorship on 4 publications\, including one review paper and three technical papers. His first author sulfide biosensor manuscript was recently published in ACS Synthetic Biology in Spring\, 2025. His research has been presented at 4 conferences\, culminating in an oral presentation at the American Institute of Chemical Engineering international conference in October\, 2024. He has been a mentor to several undergraduate students who have produced research posters at Northeastern’s undergraduate research conference. He also assisted in building the foundation of the now well-established Woolston Lab\, being one of the first two students and serving as the Lab Safety Officer. Outside of research\, Matt has many recreational hobbies including poker\, hiking\, travelling\, and fantasy sports. He is the president and founder of a local poker club in the greater Boston area. He also enjoys spending time with family and writing poetry.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-matthew-fernez/
LOCATION:420 Shillman Hall\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3396156;-71.0886534
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250605T100000
DTEND;TZID=America/New_York:20250605T120000
DTSTAMP:20260417T053000
CREATED:20250604T223853Z
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SUMMARY:ChE PhD Dissertation Defense: Victoria Duback
DESCRIPTION:Name:\nVictoria Duback \nTitle:\nPharmacokinetic and Pharmacodynamic Assessment of a T Cell-Targeted Vector for In Vivo Car-T Cell Therapy \nDate:\n06/05/2024 \nTime:\n10:00:00 AM \nCommittee Members:\nProf. Abigail Koppes (Advisor)\nProf. Ryan Koppes\nProf. Debra Auguste\nDr. Kutlu Elpek \nLocation:\nKariotis 309 \nAbstract:\nChimeric antigen receptor (CAR) T-cell therapy has demonstrated transformative efficacy in the treatment of B-cell malignancies\, particularly through autologous approaches. However\, the clinical utility of autologous CAR-T therapy is limited by complex manufacturing processes\, patient-specific variability\, and the requirement for lymphodepletion\, which can delay or prevent treatment for critically ill patients. In vivo-generated CAR-T cell therapy offers a promising alternative by enabling the direct genetic engineering of T cells within the patient\, potentially streamlining treatment and expanding access. \nThis dissertation focuses on the preclinical characterization of a CD8-targeted lentiviral fusosome designed to deliver a CD19-specific CAR transgene in vivo. The overarching objective of this work is to understand the relationship between the pharmacokinetics (PK) and pharmacodynamics (PD) of in vivo CAR-T cell generation to inform the development and clinical translation of nextgeneration gene therapy products. In vitro experiments demonstrated efficient and selective transduction of both resting and pre-activated CD8⁺ T cells\, with enhanced CAR expression and function in pre-activated populations. A humanized mouse model was optimized to evaluate vector performance in vivo\, incorporating engraftment of human PBMCs and CD19⁺ tumor cells to assess efficacy\, biodistribution\, and dose-response relationships. \nPharmacokinetic studies revealed rapid clearance of the vector in naïve mice\, while the presence of target T cells significantly prolonged vector persistence\, likely through cellular binding and internalization. Dose-dependent CAR-T cell generation and tumor suppression were observed\, with no signs of fusosome-related toxicity. Importantly\, donor-to-donor variability was noted\, emphasizing the need for robust model systems in predicting clinical outcomes. To further enhance the fusosome potency\, novel constructs incorporating CD3-mediated activation signals were engineered\, resulting in improved gene integration and functional CAR-T activity in vitro. Together\, these studies provide critical insight into the PK/PD relationship of in vivo CAR-T cell therapies and establish a strong preclinical foundation for the continued development of clinically viable\, targeted lentiviral vectors for the treatment of B cell malignancies. \n\n \nVictoria (Tori) Duback is a third-year doctoral candidate in the Chemical Engineering department at Northeastern University\, pursuing a Ph.D. in Engineering with a focus on viral vector gene delivery. She is expected to graduate in June 2025. Her research focuses on characterizing targeted gene delivery systems\, and her thesis examines the pharmacokinetics and pharmacodynamics of a T-cell-targeted vector for the treatment of B-cell malignancies. In parallel with her academic pursuits\, Tori is a seasoned industry professional\, serving as a Senior Scientist at Sana Biotechnology in the T-cell therapeutics group. Over the past several years\, she has played a pivotal role in the design and evaluation of cutting-edge immunotherapies. She leads a team of scientists dedicated to assessing the safety and efficacy of in vivo generated CAR-T cells and allogeneic CAR-T cell therapies\, conducting studies both in vivo and in vitro. Beyond the lab\, Tori is a passionate advocate for STEM education and community engagement. She has mentored high school students across the Boston Public Schools\, promoting early exposure to careers in science and engineering. Her commitment to mentoring and education reflects her belief in creating more inclusive and accessible pathways into scientific research. Looking ahead\, she aims to continue growing as a scientist in industry\, with a focus on developing safe\, effective\, and accessible therapies for patients in need. In her free time\, Tori enjoys traveling\, outdoor activities\, and spending time at the beach.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-victoria-duback/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250409T170000
DTEND;TZID=America/New_York:20250409T190000
DTSTAMP:20260417T053000
CREATED:20240722T220119Z
LAST-MODIFIED:20240722T220119Z
UID:5080-1744218000-1744225200@che.northeastern.edu
SUMMARY:Chemical Engineering Annual Awards Ceremony
DESCRIPTION:This is the annual event for our community to celebrate the department\, College\, University\, and external awards and achievements given over the past year. \n**Parking is available for a fee at Gainsborough and Renaissance Park Garages. There are also meters on Columbus Ave. Lyft and Uber are also suggested. MBTA commuters can take the Orange Line to the Ruggles stop.**
URL:https://che.northeastern.edu/event/chemical-engineering-annual-awards-ceremony/
LOCATION:Alumni Center\, 716 Columbus Ave\, 6th Floor\, Boston\, MA\, 02120\, United States
GEO:42.3376775;-71.0852898
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Alumni Center 716 Columbus Ave 6th Floor Boston MA 02120 United States;X-APPLE-RADIUS=500;X-TITLE=716 Columbus Ave\, 6th Floor:geo:-71.0852898,42.3376775
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250404T113000
DTEND;TZID=America/New_York:20250404T133000
DTSTAMP:20260417T053000
CREATED:20240722T215826Z
LAST-MODIFIED:20250331T181231Z
UID:5072-1743766200-1743773400@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Capstone Poster Session
DESCRIPTION:Come join us in celebrating our students’ capstone projects! Explore our graduating seniors’ incredible posters and groundbreaking research.
URL:https://che.northeastern.edu/event/chemical-engineering-spring-capstone-poster-session/
LOCATION:The Cabral Center\, 40 Leon Street\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250402T120000
DTEND;TZID=America/New_York:20250402T130000
DTSTAMP:20260417T053000
CREATED:20250318T181557Z
LAST-MODIFIED:20250318T181557Z
UID:5465-1743595200-1743598800@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Seminar Series: Bill Lenart
DESCRIPTION:Data-Driven Approaches Towards Controlling the Structure-Property-Processing Relationships of Soft Matter \nLocation: 135 Shillman Hall \nAbstract: Controlling the hierarchical structure of soft matter\, like polymers\, from monomer to microstructure to process design is crucial for tailoring their functional properties in advanced materials systems. However\, achieving scalable production of advanced soft materials is hindered by their inherent path-dependent behavior through a thermodynamic and kinetic landscape. Behavior arising from the kinetic limitations of macromolecular relaxation and diffusion during processing. Understanding and leveraging the path-dependence of structure-property-processing relationships in these hierarchical systems is key to addressing pressing societal challenges such as mixed plastic waste recycling and replacing synthetic plastics with natural polymer alternatives. Accomplishing this requires many large parameter datasets constructed from the combination of process analytical technology (PAT) with physical and computational experiments built into autonomous systems of experimentation\, process monitoring\, and process control. PAT can be used to generate high-fidelity datasets linking processing conditions to emergent material structure and properties. These experimental datasets (combined with offline thermal\, mechanical\, rheological\, chemical\, and structural data) then inform physics-based multiscale simulations and machine learning models. The simulations\, parameterized and validated by PAT and offline data\, allow the computational exploration of the complex processing-structure landscape and identify optimal processing windows. Hierarchical machine learning algorithms can then be trained on these combined datasets to develop predictive models capable of real-time process monitoring and control\, ultimately enabling resilient and scalable manufacturing. \nThis presentation will provide an overview of this approach\, applied to three research thrusts: (1) Autonomously Learning the Physics of Polymer Mixing\, (2) Mixed Plastic Waste Recycling\, and (3) Alginate as a Synthetic Plastic Alternative. Then we will take a deep dive into developing natural polymers\, like alginate\, as functional replacements for synthetic plastics. This will showcase the Roux Institute research model integrating fundamental and translational research with entrepreneurial engagement and workforce development. This includes a discussion on the value-chain of seaweed-derived polymers\, methods for dynamic control of chain architecture and molecular weight\, improving the quality of refined alginate\, modeling the performance and service life of alginate-based materials\, and addressing the technical limitations to creating value in a seaweed biopolymer industrial ecosystem. \n\nBill Lenart received his BSE in Polymer Science and Engineering and PhD in Macromolecular Science and Engineering from the Department of Macromolecular Science and Engineering at Case Western Reserve University under the advisement of Prof. Michael Hore. He held his first postdoc appointment in the Department of Chemical Engineering and Materials Science at the University of Minnesota with Profs. Chris Ellison and Chris Macosko and his second at the University of Chicago Pritzker School of Molecular Engineering with Prof. Stuart Rowan. Lenart started as a research scientist at the Roux Institute in Portland\, ME in August\, 2023.
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-bill-lenart/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250319T120000
DTEND;TZID=America/New_York:20250319T130000
DTSTAMP:20260417T053000
CREATED:20250121T193452Z
LAST-MODIFIED:20250121T193452Z
UID:5362-1742385600-1742389200@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Seminar Series: Kristen Wendell
DESCRIPTION:Investigating the “Black Box” of Active Learning Approaches in Engineering Education \nLocation: 135 Shillman Hall \nAbstract: In our research on undergraduate engineering education\, we seek to build theory about the details of active learning experiences in engineering courses. Engineering educators aspire to support students from all backgrounds and identities in developing deep conceptual understanding and sophisticated engineering skills. To meet this goal\, more work is needed to inform theory about individual variation and moment-to-moment processes within active learning approaches. For example\, what do students’ talk and actions look like when they are successfully learning from collaborative engineering problem solving? What specific kinds of interaction between instructors and learners foster students’ knowledge construction? \nI will present findings from three studies in which engineering faculty and education researchers collaborated to investigate these questions. We explore a “personalized problem” approach to team homework assignments in thermal fluids\, a framework for “messy” open-ended modeling problems in mechanics\, and a “responsive teaching” approach to training undergraduate learning assistants. Across the three contexts\, we conducted discourse analysis of audio recorded student interaction\, a qualitative technique common in the learning sciences. Our findings begin to characterize the task features and instructor moves that cue productive learning dynamics among undergraduate engineering students. \n\nDr. Kristen Wendell is Associate Professor of Mechanical Engineering and Education and Co-Director of the Institute for Research on Learning and Instruction (IRLI) at Tufts University. Her research group is based at the Center for Engineering Education and Outreach (CEEO). An NSF PECASE award recipient\, she serves as PI and co-PI on NSF-funded projects that investigate curriculum and instructional supports for deeper and more inclusive knowledge construction by engineering learners. She is a Deputy Editor for the Journal of Engineering Education. She teaches courses in design\, mechanics\, electronics\, and engineering education. Wendell holds a PhD in science education from Tufts and BS and MS degrees in mechanical and aerospace engineering from Princeton and MIT.
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-kristen-wendell/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250312T120000
DTEND;TZID=America/New_York:20250312T130000
DTSTAMP:20260417T053000
CREATED:20250115T194410Z
LAST-MODIFIED:20250115T194410Z
UID:5357-1741780800-1741784400@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Seminar Series: Nikhil Nair
DESCRIPTION:Understanding and mitigating host-part incompatibilities during microbial engineering \nLocation: 135 Shillman Hall \nAbstract: One of our major goals is to elucidate and highlight the unexpected outcomes that result from modifying living systems and formalize them under the umbrella of “incompatibilities”. For example\, when multiple recombinant proteins are co-expressed in bacteria like E. coli\, the cellular growth rate reduces\, due to the burden of protein expression. However\, the same system can be considered an incompatibility between the resources used for protein synthesis and the bacterial host’s intrinsic resource demands for growth. Similarly\, when a recombinant enzyme is expressed in a recombinant host\, its off-target activity on host metabolites can result in the re-distribution of fluxes through a number of host metabolic pathways. While such activity is frequently filed under promiscuous enzymatic activity\, the same can be considered an incompatibility between the enzyme and the host’s metabolic network. We have spent significant effort in systematically exploring the origin of these numerous host-part incompatibilities (where\, the added component\, like recombinant protein\, is referred to as a biological “part”) in efforts to explain previously inexplicable experimental observations. By understanding the origins of incompatibilities\, our work has revealed fundamental insights into cellular physiology and enabled the development of more robust and efficient engineered biological systems. \n\nNik Nair (naa-year) received his B.S. in Chemical and Biomolecular Engineering from Cornell University (Ithaca\, NY) in 2003. While at Cornell\, he was a founding member and lead guitarist of the not-so-well-known progressive metal band called “Rubicon”. After graduation in 2003 and a brief stint at Bristol Myers Squibb\, where he worked as a manufacturing research scientist in biotechnology purification development\, he received his M.S. and Ph.D. in Chemical and Biomolecular Engineering from the University of Illinois\, Urbana-Champaign under the guidance of Prof. Huimin Zhao. He joined Tufts in 2013 after completing a 3-year postdoctoral fellowship in Microbiology and Immunobiology at the Harvard Medical School in Prof. Ann Hochschild’s lab. He was promoted to Associate Professor with tenure in 2020. He is a recipient of the 2016 NIH Director’s New Innovator Award. The Nair Synthetic Biology & Systems Bioengineering Lab focuses on two major areas of research – 1) biosynthesis of renewable fuels and chemicals from sustainable feedstocks\, and 2) engineering proteins and microbes to improve human health. In his spare time\, which is increasingly rare\, he likes to play guitar\, golf\, and video games and watch trashy TV shows like 90 Day Fiancé and Sister Wives. His long-term plans include starting several companies based on lab-developed technologies and eventually resurrecting “Rubicon” once his young sons are old enough to master their instruments (Kiran: guitar; Liam: keyboards).
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-nikhil-nair/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250219T120000
DTEND;TZID=America/New_York:20250219T130000
DTSTAMP:20260417T053000
CREATED:20250114T212614Z
LAST-MODIFIED:20250114T212818Z
UID:5350-1739966400-1739970000@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Seminar Series: Ke Zhang
DESCRIPTION:Life in a tight spot: Spying on bacteria in complex spaces \nLocation: 135 Shillman Hall \nAbstract: Nucleic acids are programmable biomolecules that hold great promises as a therapeutic. However\, with over 40 years of development\, only a handful of nucleic acid drugs ever reached the market. The lack of greater success is in part due to the poor biopharmaceutical properties of naked nucleic acids\, which require extensive chemical modification and/or the use of a carrier system. This presentation focuses on the development of a bottlebrush polymer system for improving the delivery of oligonucleotide-based genetic medicine. Termed Brushield (brush + shield)\, the delivery technology relies upon the three-dimensional arrangement of biologically benign polymer chains to enhance the pharmacological properties of the nucleic acids. The polymer provides the conjugated oligonucleotide steric selectivity towards complementary strands vs. proteins\, which allows it to bypass many of the side effects associated with protein-DNA interactions and achieve bioactivity in a number of disease models. \n\n Dr. Ke Zhang obtained his BS degree in 2005 in Applied Chemistry from Nanjing University of Technology\, China. He then studied polymer chemistry with Prof. Karen Wooley at Washington University in St. Louis\, focusing on shell-crosslinked knedel-like nanoparticles and gene delivery\, obtaining a PhD degree in Chemistry in 2009. Thereafter\, Dr. Zhang was a postdoctoral fellow in the laboratory of Prof. Chad Mirkin at Northwestern University to develop hollow spherical nucleic acids\, a carrier-free platform for gene regulation. In 2012\, Dr. Zhang joined Northeastern University as an Assistant Professor of Chemistry and was promoted to Associate in 2017 and to Full in 2022. His current research includes the design and synthesis of unique polymer superstructures\, nucleic acid-polymer conjugates\, and genetic nanomedicine. Dr. Zhang was recognized as a Kabiller Rising Star in Nanomedicine (2023)\, a Pioneering Investigator by Polymer Chemistry (2021)\, Emerging Investigator by Journal of Materials Chemistry B (2020)\, ACS PMSE Young Investigator (2018)\, Nano Research Young Innovator (2017)\, ACS PRF Doctoral New Investigator (2014)\, and by an NSF CAREER award (2014).
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-ke-zhang/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250129T120000
DTEND;TZID=America/New_York:20250129T130000
DTSTAMP:20260417T053000
CREATED:20250114T212735Z
LAST-MODIFIED:20250114T212735Z
UID:5353-1738152000-1738155600@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Seminar Series: Sara H. Rouhanifard
DESCRIPTION:Developing tools for single-molecule sequencing and imaging of RNA modifications \nLocation: 135 Shillman Hall \nAbstract: Despite every cell in the human body having the same genetic makeup\, gene expression varies greatly between them. The process of DNA transcription into RNA\, along with subsequent post-transcriptional modifications\, is crucial for achieving this variability and enabling cell specialization. To manage and potentially correct abnormal gene expression\, it’s essential to understand these complex regulatory steps. This understanding relies on developing advanced tools for single-molecule identification\, quantification and imaging of RNAs. \nIn this talk\, I will detail our efforts to identify newly modified mRNAs in human cells using direct\, long-read sequencing technologies. We are leveraging this technology to explore how RNA modifications impact the physiological functions of developing neurons and immune cells from the human body. By visualizing RNA populations within cells\, we can gain insights into their functions and mechanisms—localization often suggests function\, while single-cell distribution can reveal underlying mechanisms. \nI will also discuss our work on developing methods for site specific imaging of modified and newly transcribed RNAs\, including new chemistry designed for live-cell imaging with single-molecule resolution. These innovations promise to deepen our understanding of gene regulation and pave the way for new therapeutic approaches\, such as vaccines for infectious disease and advanced gene therapies. \n\n Prof. Rouhanifard received her B.S. in Biochemistry and Molecular Biology from UMass Amherst in 2007. She then completed a Ph.D. in Biochemistry at the Albert Einstein College of Medicine under the supervision of Peng Wu\, developing chemical tools to probe glycosylation in cells using biorthogonal chemistry. She then joined the laboratory of Arjun Raj Bioengineering department at the University of Pennsylvania as a postdoctoral associate and a NIH Ruth S. Kirschstein F32 National Research Service Award fellow\, where she developed single-molecule approaches to image RNA in cells. She joined the Northeastern Bioengineering department as an assistant professor in 2019. Her primary research interests lie in understanding the epitranscriptome and related mechanisms that govern cellular differentiation and response to external stimuli. The Rouhanifard laboratory develops quantitative\, single-molecule sequencing and imaging approaches using new chemistry to identify and perturb sites of RNA modifications to reveal specific biological functions that may be exploited for the development of future therapeutics.
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-sara-h-rouhanifard/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241213T140000
DTEND;TZID=America/New_York:20241213T160000
DTSTAMP:20260417T053000
CREATED:20241202T194950Z
LAST-MODIFIED:20241202T194950Z
UID:5314-1734098400-1734105600@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Yuan Li
DESCRIPTION:Name:\nYuan Li \nTitle:\nEstablishing a Physiologically Relevant Upper Gastrointestinal In Vitro Model Incorporating Bile Salts and Simplified Commensal Microbial Consortium \nDate:\n12/13/2024 \nTime:\n2:00:00 PM \nCommittee Members:\nProf. Rebecca Carrier (Advisor)\nProf. Abigail Koppes\nProf. Erel Levine\nProf. Jiahe Li \nLocation:\nEXP 610-A \nAbstract:\nBacteria-epithelial-immune crosstalk plays crucial roles in intestinal physiology. Bile salts (BS) act as critical modulators of these interactions\, influencing health and disease. Tools for studying interactions between BS\, microbes\, and host cells within the human intestinal mucosa are lacking. \nIn this project\, we developed in vitro intestinal models for studying bacteria-epithelial-immune crosstalk. First\, the impacts of individual BS (sodium taurocholate\, NaTC; sodium glycochenodeoxycholate\, NaGCDC; and sodium tauroursodeoxycholate\, NaTUDC) on human primary intestinal epithelial monolayer co-cultures with Escherichia coli were studied. We observed that high BS concentrations disrupted barrier function\, as evidenced by reduced transepithelial electrical resistance (TEER)\, with NaGCDC causing the most significant damage. Interestingly\, the addition of phyosphatidylcholine (PC) and E. coli were observed to mitigate the BS-induced monolayer TEER reductions. \nTo enhance the model’s physiological relevance\, we next incorporated a simplified model bile (including NaTC\, NaGCDC\, NaTUDC\, and PC)\, an apical hypoxic environment\, dendritic cells\, and a simplified commensal microbial consortium (Streptococcus mitis\, Clostridium bifermentans\, Prevotella melaninogenica\, and Bifidobacterium longum). 4/1 mM concentrations of BS/PC micelles were observed to damage the epithelial barrier under hypoxic but not normoxic conditions. However\, incorporation of the bacterial consortium protected the epithelium from BS/PC – associated damage. Furthermore\, the presence of BS/PC alleviated barrier damage and inflammatory response induced by co-culture with the bacterial consortium\, potentially in part through modulation of bacterial growth. In addition\, we observed thicker mucus layers not only impacted the growth of consortium strains\, resulting in enhanced growth of the probiotic Bifidobacterium longum\, but also reduced inflammatory responses to bacteria and BS/PC-induced epithelial damage. In general\, our in vitro model revealed that commensal microbes mitigate BS and BS/PC toxicity to the epithelial monolayer\, while BS helps alleviate monolayer damage and inflammatory response caused by commensal microbes. \nIn preparation for transferring the developed model from static cell culture inserts to microfluidic devices for mimicking intestinal fluidic stimuli and enabling facile visualization of the mucosal interface\, we designed a gut-on-chip platform with a vertical hydrogel-cultured epithelial monolayer. Three hydrogels (crosslinked collagen type I\, PEG-VS\, and PEG-SG-PLL) were evaluated for compatibility with human primary intestinal epithelial stem cells (HPIESCs). Collagen type I and PEG-SG-PLL were found to support HPIESC adhesion and monolayer formation\, but collagen lost structural integrity under flow. PEG-VS\, though functionalized with cell-binding peptides\, only enabled partial monolayer formation. Notably\, encapsulating organoids in PEG-VS near the gel-medium interface enabled crypt-like monolayer formation through organoid-driven gel re-structuring. Furthermore\, we found that flow enhanced epithelial differentiation on PEG-SG-PLL and PEG-VS (encapsulation method)\, leading to thicker monolayers with taller columnar cells compared to static culture. These findings show PEG-SG-PLL and PEG-VS are good candidates for enabling transition of the bile-intestinal model to microfluidic chip platforms.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-yuan-li/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241210T140000
DTEND;TZID=America/New_York:20241210T160000
DTSTAMP:20260417T053000
CREATED:20241202T194836Z
LAST-MODIFIED:20241202T194836Z
UID:5310-1733839200-1733846400@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Peng Zhao
DESCRIPTION:Name:\nPeng Zhao \nTitle:\nImpact of ECM-Based Hydrogel Delivery Vehicle Properties on Cell Survival in a 3D In Vitro Injection Model for Retinal Progenitor Cell Transplantation \nDate:\n12/10/2024 \nTime:\n2:00:00 PM \nCommittee Members:\nProf. Rebecca Carrier (Advisor)\nProf. Abigail Koppes\nProf. Sidi Bencherif\nProf. Michael Young \nLocation:\nEXP 610-A \nAbstract:\nAge-related macular degeneration (AMD) is the leading cause of vision loss globally and a form of retinal degenerative (RD) disease. Current treatments\, such as gene therapy\, drugs\, laser procedures\, and neuroprotective approaches\, cannot restore the photoreceptors lost in RD diseases. Cell transplantation into the subretinal space shows potential to enhance visual function\, but low cell survival and efflux from the injection site present major obstacles. Mechanical forces during injection can severely damage cells\, and the host microenvironment may further contribute to cell death. Following high-density subretinal injection\, a compact cell bolus may form\, resulting in nutrient depletion\, low oxygen levels\, pH imbalances\, and waste accumulation—factors that exacerbate cell death. \nBiomaterial scaffolds have been employed to improve cell survival and differentiation\, though the ideal scaffold cues for supporting transplanted cell survival and integration remain undetermined. In this study\, we developed a three-dimensional (3D) in vitro injection model to simulate subretinal bolus injection. Using this model\, we found that the injection process and bolus microenvironment negatively impact human retinal progenitor cell (hRPC) viability\, promoting apoptosis. Alginate-based hydrogels of varying stiffness and extracellular matrix (ECM) molecule compositions were created using factorial design. hRPC viability\, apoptosis\, and migration within the formed hydrogels were investigated through the 3D in vitro injection model and a 3D invasion assay. Factorial design analysis revealed that higher stiffness and the inclusion of laminin and hyaluronic acid enhance hRPC survival and 3D migration. \nOne challenge with studying cell responses in the context of cell transplantation is the inability to easily visualize cells at the transplantation site over time. Compared to traditional in vitro cultures\, retinal explant models that retain native tissue structure and neuronal connections could provide physiologically relevant insights. Here\, we developed a novel explant model for hRPC transplantation\, wherein alginate-based hydrogels containing hRPCs were injected adjacent to cross-sectional retinal tissue slices. This setup allows visualization of the cells’ position relative to retinal tissue layers over time. Key cell behaviors\, including migration\, attachment\, invasion\, viability\, and apoptosis\, were tracked in real-time using confocal microscopy.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-peng-zhao/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241204T120000
DTEND;TZID=America/New_York:20241204T130000
DTSTAMP:20260417T053000
CREATED:20240806T211609Z
LAST-MODIFIED:20241101T185914Z
UID:5130-1733313600-1733317200@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Omokolade Adebowale
DESCRIPTION:Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies \nLocation: 305 Shillman Hall \nAbstract: Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies Therapeutic immune cells have the potential to treat complex diseases. Some therapies\, such as CAR T cells\, are effective against blood cancers but are not effective against solid cancers\, which comprise about 90% of adult cancers. A key requirement of the role of therapeutic cells in tumor eradication is their ability to migrate to and infiltrate the tumor. To accomplish this\, cells navigate various mechanoimmunological factors\, such as tissue viscoelasticity. One consequence of viscoelasticity is time-dependent stress relaxation – a decrease in stress in response to applied deformation. However\, the mechanisms by which viscoelasticity regulates migration are not fully understood. In addition\, limited studies have quantitatively compared the transport of cell therapies in tissue-like environments. My research aims to address these research gaps. To address the potential role of viscoelasticity on 3D cell migration\, I developed hydrogels that mimic the stress relaxation behavior of native tissues. I found that enhanced stress relaxation potentiates monocyte migration. Mechanistically\, our data support a model whereby WASP-mediated actin polymerization generates physical force at the leading edge of the cell to generate micron-sized channels for cells to migrate through. In a separate project\, I integrated macrophage phenotype and morphometric transitions. Together\, our studies establish a platform to determine the role of mechanical cues in shaping the immune response and to leverage fundamental mechanisms to enable the rational design of “living drugs.” \n\nKolade Adebowale will join the Shu Chien-Gene Lay Department of Bioengineering as an assistant professor in Spring 2025. Dr. Adebowale received his Ph.D. from Stanford University in 2021 under the guidance of Professor Ovijit Chaudhuri. Dr. Adebowale is a postdoctoral fellow with Professor Samir Mitragotri at Harvard University. While at Stanford\, Dr. Adebowale received the NSF GRFP\, a Stanford Graduate Fellowship\, and an NIH F31 grant. At Harvard\, Dr. Adebowale was awarded an NSF Ascend – MPS postdoctoral fellowship and was an NIH MOSAIC K99/R00 scholar. Dr. Adebowale’s main research areas are biomaterials\, mechanobiology\, and immunology. He seeks to integrate engineering design principles in cancer immunology to enable rational engineering and prediction of effective\, next-generation immune cell therapies. Furthermore\, Dr. Adebowale strives to understand how the complex functionality of the immune system arises from mechanical cues and simple biophysical principles. Dr. Adebowale is excited to teach and mentor the next generation of scientists and engineers.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-omokolade-adebowale/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241125T110000
DTEND;TZID=America/New_York:20241125T130000
DTSTAMP:20260417T053000
CREATED:20241120T011317Z
LAST-MODIFIED:20241120T011317Z
UID:5271-1732532400-1732539600@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Dominick Guida
DESCRIPTION:  \nName: \n\nDominick Guida \nTitle: \nCharacterizing and Modeling Heterogeneity in Alkaline Zn-MnO2 Batteries Using Synchrotron CT and EDXRD \nDate:\n11/25/2024 \nTime:\n11:00:00 AM \nCommittee Members:\nProf. Joshua Gallaway (Advisor)\nProf. Leila Deravi\nProf. Richard West \nLocation:\nEXP 610 and Teams \nAbstract:\nAlkaline Zn-MnO2 cells have dominated the primary battery industry for decades\, enabled by their inherent safety\, minimal environmental impact\, and low cost. Despite their widespread use\, the internal phenomena that occur within alkaline Zn anodes and MnO2 cathodes remain incompletely characterized. Within alkaline Zn anodes\, unaccounted discharge phenomena result in an inability to predict active material distribution\, internal resistance\, and eventual cell failure. In the MnO2 cathode\, heterogeneous protonation and subsequent gradient relaxation impacts cell performance\, yet remains incompletely characterized. A robust understanding of the function of alkaline Zn-MnO2 batteries is a necessary step in further improving their performance and expanding on their usefulness. \nTo better understand Zn anodes\, high resolution computed tomography (CT) was used to determine the material distribution and morphology of active phases in situ for Zn anodes discharged under various conditions. A novel algorithm was then developed to segment each individual phase from the CT data and obtain 1-D radial material distributions for direct comparison with computational modeling. The evaluation of material distributions and battery performance data provided invaluable insights on the function of alkaline Zn anodes\, including percolation effects on the Zn particle network\, maintenance of the electronic network through ZnO bridging\, and solid phase mobility due to granular flow. Identifying these phenomena have been a significant step towards elucidating the functional mechanisms within alkaline Zn anodes\, representing critical behaviors that had previously gone undetected. Not accounting for such pivotal electrode characteristics provides ample evidence as to why early modeling attempts failed to adequately capture Zn anode function. By incorporating these newly discovered phenomena\, it is now possible to predict the behavior of alkaline Zn anodes with excellent accuracy. \nIn studying MnO2 cathodes\, spatially resolved energy dispersive X-ray diffraction (EDXRD) was used to measure the heterogeneity in protonation of the active material. When using a pulsed discharge protocol\, it was identified that a significant gradient in MnO2 proton content forms across the cathode thickness during a discharge pulse and partially relaxes during a subsequent rest. The rate of gradient relaxation suggested a redox-based mechanism for proton redistribution\, which was not accurately predicted when using typical kinetic models. A fundamental kinetics experiment was performed on prismatic MnO2 electrodes\, identifying that the core-shell discharge behavior of MnO2\, where undischarged cores of MnO2 are surrounded by shells of MnOOH discharge products\, has significant implications for the reaction kinetics. As a result\, the kinetic expression used for MnO2 cathodes was modified to account for the effects of proton transport limitations induced from the MnOOH shell\, as well as kinetic effects of the active particle surface. This new expression dramatically improved MnO2 cathode model accuracy\, with simulated proton gradient formation and relaxation rates being in excellent agreement with EDXRD measurements. \nThe experimentally driven insights into alkaline Zn anodes and MnO2 cathodes have led to significant discoveries of previously unknown and uncharacterized phenomena that impact cell performance. These results were then incorporated into computational models to improve their accuracy and effectiveness\, while also representing an improved overall understanding of alkaline Zn-MnO2 batteries.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-dominick-guida/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241106T120000
DTEND;TZID=America/New_York:20241106T130000
DTSTAMP:20260417T053000
CREATED:20240806T211708Z
LAST-MODIFIED:20241101T191234Z
UID:5133-1730894400-1730898000@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Susan Roberts
DESCRIPTION:Molecular Engineering for Production of Anti-cancer Compounds in Plant Cell Culture \nLocation: 305 Shillman Hall \nAbstract: Our research is focused on cellular engineering and design of bioprocesses using plant-based systems. Plants produce sophisticated small molecules that play key roles in defense against predators and environmental elements. These natural products are synthesized through specialized metabolic pathways\, that have both shared and unique components when compared amongst plant systems. These specialized metabolites are useful in a variety of societal applications including as nutraceuticals\, flavorings\, colorings and pharmaceuticals. The supply of these compounds is often hindered due to low yields in nature and the inability to chemically synthesize at scale. We use plant cell culture technology as both a system of study and a scalable production system due to the ability to engineer cells and the environment to optimize accumulation of products of interest. Our group uses a combination of traditional bioprocess engineering techniques (e.g.\, bioreactor design\, cell culture\, media optimization) and modern molecular biology and analytical chemistry techniques (e.g.\, gene transfer\, transcriptomics analyses\, UPLC). Today\, I will focus my talk on molecular engineering strategies to understand and increase paclitaxel production in Taxus plant cell suspension culture. We have applied transcriptomics analyses and genetic engineering tools to understand and manipulate the pathway to paclitaxel\, identify paclitaxel transporters\, and engineer epigenetic mechanisms that can lead to decreased production over time in culture. \n\nDr. Susan Roberts is Professor and Head of Chemical Engineering at WPI. She received her BS degree in Chemical Engineering from WPI in 1992\, PhD in Chemical Engineering from Cornell University in 1998\, served on the faculty at UMass Amherst Chemical Engineering for 17 years and joined WPI as Professor and Head in 2015. Her work has raised over $10M from NSF\, NIH\, industry and government. She is a program builder and has established new interdisciplinary research and education programs through strategic partnerships and external funding from the NSF ADVANCE Program\, NIIMBL Workforce Development Award\, Mass Life Sciences Center\, NSF IGERT and NIH T32 Programs. She is a passionate about faculty development\, training interdisciplinary engineers\, innovating graduate education and advocating for advancement of women and underrepresented groups in STEM fields.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-susan-roberts/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241104T130000
DTEND;TZID=America/New_York:20241104T150000
DTSTAMP:20260417T053000
CREATED:20241031T175809Z
LAST-MODIFIED:20241031T175809Z
UID:5236-1730725200-1730732400@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Rudolf Abdelmessih
DESCRIPTION:Name:\nRudolf Abdelmessih \nTitle: \nInvestigating Strategies for Engineering More Efficient Drug Nanocarriers for Treatment of Human Metastatic Breast Cancer the Impact of Hydrophobic Drug Encapsulation on the Properties of Lipid-Based Nanoparticles and Drug Bioavailability \nDate:\n11/04/2024 \nTime:\n1:00:00 PM \nCommittee Members:\nProf. Debra T. Auguste (Advisor)\nProf. Rebecca Carrier\nProf. Stephen Hatfield\nProf. Francisco Hung\nProf. Benjamin Woolston \nLocation:\nEXP 401-A \nAbstract:\nA significant challenge in cancer treatment is the delivery of water-insoluble\, hydrophobic drugs to tumor tissue at concentrations that are therapeutically effective. One way to address this challenge is by encapsulating hydrophobic drugs into drug delivery systems that would allow them to circulate with blood and diffuse into tumor tissue. Lipid-based nanoparticles (LNPs) constitute most of the drug delivery systems currently approved for clinical use\, owing to their degradability\, lack of toxicity and their wide range of tunable properties. Liposomes are one example of LNPs; they are spherical vesicles comprised of a bilayer phospholipid membrane surrounding an aqueous core\, that can be used to encapsulate hydrophobic drugs. However\, hydrophobic drug encapsulation can change the structure and mechanical properties of the lipid\nmembrane of liposomes\, and the way they interact with cancer cells. Herein\, we investigated the impact of encapsulating different hydrophobic\, anticancer drugs into liposomes on cellular uptake\, tumor accumulation\, gene expression and tumor growth\, in metastatic breast cancer (MBC). \nOur data show that the encapsulation of an LPA receptor antagonist (Ki16425) into liposomes decreased the stiffness of the lipid membrane\, and enhanced their cellular internalization\, and tumor accumulation. Moreover\, we show that the encapsulation of an HDAC inhibitor (NVP) into liposomes increased their cellular uptake\, upregulated the expression of tumor suppressor genes\, and led to a significant cell death in MBC cells. Similarly\, we tested the effect of encapsulating an adenosine receptor antagonist (KW-6002) in a liposomal formulation that can activate cancer-related immune responses. \nIn conclusion\, our results offer insights into the chemical and mechanical behavior of drug-lipid complexes that can impact cellular internalization and tumor delivery\, and may aid in the treatment of MBC.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-rudolf-abdelmessih/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241016T120000
DTEND;TZID=America/New_York:20241016T130000
DTSTAMP:20260417T053000
CREATED:20240806T211755Z
LAST-MODIFIED:20240826T181712Z
UID:5136-1729080000-1729083600@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Niya Sa
DESCRIPTION:Probe the Dynamic Interfaces of Beyond Lithium-ion Energy Storage Systems \nLocation: 305 Shillman Hall \nAbstract: Rapid growth of technology in the past few decades has spurred a demand for advanced energy storage devices. The invention of a more advanced battery system with higher levels of performance will be a groundbreaking discovery in the rechargeable battery field. Multivalent chemistry offers promising benefits in the development of beyond lithium-ion technologies. The direct usage of the multivalent metal anode is essential to enhance the energy density of the multivalent ion battery. For instance\, Magnesium\, Calcium and Zinc offer an immense alternative to the existing Li-ion batteries due to their multivalent nature and vast abundance in the Earth’s crust. However\, possible film formation at the solid/liquid interface complicates the electrochemical properties of such systems. The least understood solid electrolyte interphase (SEI)\, its formation and dynamic evolution has not been extensively explored for multivalent battery systems with many unknowns remain to be answered. We aim to use electroanalytical tools to probe the dynamic evolution of the solid electrolyte interface in-situ for multivalent systems and investigate its correlation with the electrochemical processes. This presentation focuses on some very recent research findings from our team for understanding the interfacial chemistry\, evolution\, and stability for different multivalent battery systems. \n\nProfessor Niya Sa is an Associate Professor in the Department of Chemistry at the University of Massachusetts Boston. She received her Ph.D. from the Analytical Chemistry (Electroanalytical Chemistry) program at Indiana University-Bloomington\, where she worked with Professor Lane A. Baker on understanding fundamental ion transport phenomena in confined regime. She extended her training working as a postdoc research fellow at the Electrochemical Energy Storage Division at Argonne National Lab. Her research focus at Argonne was to develop beyond lithium-ion battery materials. She joined the University of Massachusetts in 2017 as an Assistant Professor\, and her current research interests include probing the electrochemical interfaces for energy materials\, development of new electrolytes for next-generation energy storage systems. Niya is a recipient of the NSF CAREER Award. She also received the Endowed Faculty Career Development Award\, Joseph P. Healey Award\, and the Early Career Research Excellence Award from University of Massachusetts.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-niya-sa/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241010T170000
DTEND;TZID=America/New_York:20241010T190000
DTSTAMP:20260417T053000
CREATED:20240806T175016Z
LAST-MODIFIED:20240806T175016Z
UID:5123-1728579600-1728586800@che.northeastern.edu
SUMMARY:SOURCE\, the Showcase of Opportunities for Undergraduate Research and Creative Endeavor
DESCRIPTION:Learn more about what cutting-edge research and creative endeavors look like at Northeastern. Talk one-on-one with faculty from across the colleges about their work – and learn how you can get involved in projects during your time at Northeastern. \nSOURCE is a collaboration between Bouvé College of Health Sciences; College of Arts\, Media and Design; College of Engineering; College of Science; College of Social Sciences and Humanities; D’Amore-McKim School of Business; and Khoury College of Computer Science. It is coordinated by Undergraduate Research and Fellowships on behalf of the Office of the Chancellor. \nPlease write to URF@Northeastern.edu with any questions.
URL:https://che.northeastern.edu/event/source-the-showcase-of-opportunities-for-undergraduate-research-and-creative-endeavor-2/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241009T120000
DTEND;TZID=America/New_York:20241009T130000
DTSTAMP:20260417T053000
CREATED:20240806T211835Z
LAST-MODIFIED:20240916T185711Z
UID:5139-1728475200-1728478800@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: William Tisdale
DESCRIPTION:Hybrid Semiconductor Nanomaterials \nLocation: 305 Shillman Hall \nAbstract: Hybrid organic-inorganic semiconductor nanomaterials – including colloidal quantum dots (QDs)\, 2D halide perovskites\, and metal-organic chalcogenolates (MOCs) – are excitonic materials with applications ranging from solar cells to light-emitting devices to quantum computing and quantum cryptography. In these emerging materials\, the combination of quantum and dielectric confinement\, strong exciton-phonon coupling\, and dimensionality reduction offer unprecedented opportunities for controlling light-matter-charge interactions through chemistry. In this talk\, I will describe recent work from my lab on the synthesis of hybrid semiconductor nanomaterials and our evolving understanding of how structure and chemical functionalization influence excited state dynamics. Using a combination of ultrafast laser spectroscopy\, time-resolved optical microscopy\, and kinetic modeling\, we will explore the impact of nonequilibrium population dynamics on excited state transport phenomena and the emergence of unique electronic and vibrational phenomena. \n\nWill Tisdale is the Warren K. Lewis Professor of Chemical Engineering at MIT\, where he has been teaching and leading a research team since 2012. His research program is focused on the discovery of hybrid organic-inorganic nanomaterials capable of transporting energy in new ways\, and on the use and development of ultrafast laser spectroscopy methods and advanced optical microscopy techniques for probing dynamics at the nanoscale. Will’s contributions to research have been recognized by the Presidential Early Career Award for Scientists and Engineers (PECASE)\, an Alfred P. Sloan Fellowship\, the Camille Dreyfus Teacher-Scholar Award\, the DOE Early Career Award\, the NSF CAREER Award\, the AIChE NSEF Young Investigator Award\, and a 3M Non-Tenured Faculty Award. \nFor his dedication to undergraduate teaching Will has received MIT’s highest honor\, the MacVicar Fellowship\, as well as the student-selected Baker Award\, the School of Engineering’s Amare Bose Award\, and he is a 7-time recipient of the C. Michael Mohr Undergraduate Teaching Award\, which is voted annually by the Chemical Engineering undergraduate students at MIT. Will graduated magna cum laude from the University of Delaware in 2005\, earning an Honors B.S. in Chemical Engineering\, with Distinction\, and minoring in Economics. He earned a Ph.D. in Chemical Engineering at the University of Minnesota in 2010\, then studied as a postdoctoral associate in the Research Laboratory of Electronics at MIT before joining the faculty in Chemical Engineering in 2012. \n 
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-william-tisdale/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241002T120000
DTEND;TZID=America/New_York:20241002T130000
DTSTAMP:20260417T053000
CREATED:20240717T231924Z
LAST-MODIFIED:20240916T174446Z
UID:5010-1727870400-1727874000@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Sujit Datta
DESCRIPTION:Life in a tight spot: Spying on bacteria in complex spaces \nLocation: Snell Engineering Center 168 \nAbstract: Bacteria are arguably the simplest form of life; and yet\, as multi-cellular collectives\, they perform complex functions critical to environment\, food\, health\, and industry. What principles govern how complex behaviors emerge in bacterial collectives? And how can we harness them to control bacterial behavior? In this talk\, I will describe my group’s work addressing this question using tools from soft matter engineering\, 3D imaging\, and biophysical modeling. We have developed the ability to (i) directly visualize bacteria from the scale of a single cell to that of an entire multi-cellular collective\, (ii) 3D-print precisely structured collectives\, and (iii) model their large-scale motion and growth in complex environments. I will describe how\, using this approach\, we are developing new ways to predict and control how bacterial collectives — and potentially other forms of “active matter” — spread large distances\, adapt shape to resist perturbations\, and self-regulate growth to access more space by processing chemical information in their local environments. \n\nSujit Datta is a Professor of Chemical Engineering\, Bioengineering\, and Biophysics at Caltech. Prior\, he was at Princeton University\, where he started his faculty career in 2017 and was promoted to Associate Professor of Chemical and Biological Engineering in 2022. \nSujit earned a BA in Mathematics and Physics and an MS in Physics in 2008 from the University of Pennsylvania\, and then a PhD in Physics in 2013 from Harvard\, where he studied fluid dynamics and instabilities in soft and disordered media with Dave Weitz. His postdoctoral training was in Chemical Engineering at Caltech\, where he studied the biophysics of the gut with Rustem Ismagilov. \nThe Datta Lab studies the dynamics\, self-organization\, and applications of complex\, soft (“squishy”)\, and living systems\, with a focus on complex fluids\, gels\, and bacterial communities/active matter\, motivated by challenges in biotechnology\, energy\, environment\, and medicine. Their work integrates microscopy\, microfluidics\, materials science\, and biophysical characterization with theoretical & computational modeling\, applying ideas from fluid and solid mechanics\, colloidal science\, polymer physics\, statistical mechanics\, and network science. Altogether\, this research program has revealed and shed new light on the fascinating behaviors manifested by complex fluids and bacterial populations in complex environments\, guiding the development of new approaches to environmental remediation\, energy production\, agriculture\, water security\, and biotechnology. \nSujit’s scholarship has been recognized by awards from a broad range of different communities\, reflecting its multidisciplinary nature\, including through the AIChE Allan P. Colburn and 35 Under 35 Awards\, three awards from the APS (Early Career Award in Biological Physics\, Andreas Acrivos Award in Fluid Dynamics\, and Apker Award)\, Pew Biomedical Scholar Award\, Society of Rheology Arthur Metzner Award\, ACS Unilever Award\, Camille Dreyfus Teacher-Scholar Award\, NSF CAREER Award\, and multiple commendations for teaching. In addition to leading professional activities for a number of scientific societies and agencies\, Sujit serves on the editorial boards of Annual Reviews of Condensed Matter Physics and the Journal of Non-Newtonian Fluid Mechanics.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-sujit-datta/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240925T120000
DTEND;TZID=America/New_York:20240925T130000
DTSTAMP:20260417T053000
CREATED:20240717T231837Z
LAST-MODIFIED:20240828T212208Z
UID:5004-1727265600-1727269200@che.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Matthew J. Eckleman
DESCRIPTION:Sustainability in the Chemicals Sector: From Green Synthesis to Global Systems\nLocation: 305 Shillman Hall \nAbstract: The chemicals sector is undergoing a transformation driven by decarbonization\, shifting feedstocks\, circularity\, and increasing demand for low-carbon\, non-toxic products. Globally\, chemicals production is responsible for approximately 5% of worldwide greenhouse gas emissions\, stemming from fuel combustion\, process emissions\, and product use. A wide variety of new technologies are being proposed to decarbonize chemicals manufacturing\, but in many cases their environmental benefits are not obvious and they could even have the potential to degrade other aspects of environmental quality. Robust environmental assessment of energy use\, resource inputs\, and emissions over the entire chemicals life cycle is essential for to ensure that proposed green technologies will actually deliver promised environmental benefits. \nTo aid in this\, life cycle assessment (LCA)\, techno-economic analysis (TEA)\, and related tools are increasingly being used in regulation\, certification\, and corporate decision-making. For example\, US biofuels must meet a life cycle greenhouse gas emissions reduction target to be qualified as a renewable fuel\, including emissions from production of chemical inputs that can drive overall results. \nThis seminar will present several LCA-based sustainability modeling projects in the chemicals industry\, from single green syntheses to analysis of technology at the global systems scale. Case studies will include bio-based feedstocks\, decarbonization efforts in pharmaceuticals and medicines\, low-carbon fuels\, and electrochemical synthesis techniques. \n\nMatthew Eckelman is an Associate Professor of civil and environmental engineering and affiliated faculty in chemical engineering at Northeastern\, and adjunct Associate Professor at Yale School of Public Health. His research focuses on process simulation and life cycle assessment for industrial manufacturing\, including primary metals\, commodity and fine chemicals\, pharmaceuticals\, bio- and nano-materials. Dr. Eckelman worked previously for the Massachusetts executive office of environmental affairs and consults regularly on sustainability-related projects for industrial companies and non-profit institutions. He was awarded an NSF CAREER award in environmental sustainability in 2015 and is a member of the Lancet Countdown on Health and Climate Change. He holds a PhD in Chemical and Environmental Engineering from Yale\, where he was affiliated with the Center for Industrial Ecology and the Center for Green Chemistry and Engineering.
URL:https://che.northeastern.edu/event/chemical-engineering-fall-seminar-series-matthew-j-eckleman/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240917T153000
DTEND;TZID=America/New_York:20240917T173000
DTSTAMP:20260417T053000
CREATED:20240722T220255Z
LAST-MODIFIED:20240722T220255Z
UID:5085-1726587000-1726594200@che.northeastern.edu
SUMMARY:Chemical Engineering Welcome Back Event
DESCRIPTION:Please join the Chemical Engineering Department for our Welcome Back Event in Robinson Quad on September 13th from 3:30-5:30 PM. \nAll Chemical Engineering students\, both new and returning\, undergraduate and graduate\, are invited! \nCome enjoy some great food and get to know your professors and fellow students!
URL:https://che.northeastern.edu/event/chemical-engineering-welcome-back-event/
LOCATION:Robinson Quad Tents\, 360 Huntington Ave\, outside Mugar\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240917T100000
DTEND;TZID=America/New_York:20240917T143000
DTSTAMP:20260417T053000
CREATED:20240722T220020Z
LAST-MODIFIED:20240722T220020Z
UID:5077-1726567200-1726583400@che.northeastern.edu
SUMMARY:Chemical Engineering Research Showcase
DESCRIPTION:Join us for our Annual Chemical Engineering Research Showcase in the Cabral Center! Every year\, our Chemical Engineering PhD students and select faculty members present their work at the Research Showcase in the form of Oral Presentations\, Poster Sessions\, and 5-minute Presentations. All are welcome to attend.
URL:https://che.northeastern.edu/event/chemical-engineering-research-showcase/
LOCATION:The Cabral Center\, 40 Leon Street\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240911T090000
DTEND;TZID=America/New_York:20240911T110000
DTSTAMP:20260417T053000
CREATED:20240903T175736Z
LAST-MODIFIED:20240903T175736Z
UID:5173-1726045200-1726052400@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Ronodeep Mitra
DESCRIPTION:Name:\nRonodeep Mitra \nTitle: \nGlycocalyx Therapy to Restore Anti-Atherosclerotic Endothelial Cell Function \nDate:\n9/11/2024 \nTime:\n9:00:00 AM \nCommittee Members:\nProf. Eno Ebong (Advisor)\nProf. Mansoor Amiji\nProf. Rebecca Carrier\nProf. Arthur J. Coury\nProf. Jessica M. Oakes \nLocation:\nEXP 610 and Zoom \nAbstract:\nThe endothelial cell (EC) glycocalyx (GCX) is a negatively charged complex sugar-rich layer that lines the endothelium. It is an important contributor to the physical and biochemical health of the vasculature and endothelium\, while mediating mechanotransduction and vascular signaling. For example\, when exposed to physiological (unidirectional and uniform in magnitude) levels of shear stress from the mechanical force of blood flow\, the GCX is abundant and aids in the production of vasodilator nitric oxide (NO)\, which regulates vascular tone. Furthermore\, the dynamics of the flow-regulated GCX determine the structural integrity of connexin proteins that comprises interendothelial gap junctions and control the flow of communication between neighboring ECs. Finally\, the GCX acts as a physical barrier to numerous components in circulating blood\, including low-density lipoproteins (LDLs) and inflammatory cells such as monocytes that differentiate into macrophages and platelets. \nLoss of the EC GCX can be attributed to disturbed vasculature blood flow patterns. This condition renders the endothelium as adhesive and permeable\, resulting in infiltration of the vessel walls by blood circulating LDLs\, compromising active EC-EC communication via interendothelial gap junctions\, and reduction in NO production\, leading to vasoconstriction. These phenotypes lead to vascular dysfunction\, atherosclerosis\, and other serious secondary cardiovascular events\, such as myocardial infarctions and strokes. Hence\, we propose either repurposing therapies that were\nnot originally indicated for GCX therapy or the development of novel GCX therapies and hypothesize that targeting the EC GCX will restore vascular function and prevent further downstream cardiovascular events\, such as atherosclerosis. \nWe first tested our hypothesis by assessing the efficacy of repurposing diosmin\, a flavanone glycoside of diosmetin\, which is a nutraceutical used to currently treat chronic venous insufficiency. Previous studies have shown diosmin’s potent anti-inflammatory and anti-oxidant properties on the endothelium. Hence\, we wanted to determine if diosmin would repair mechanically damaged endothelial GCX in regions of disturbed flow (DF) patterns and restore anti-atherosclerotic endothelium mechanotransduction function. For this study\, we utilized a unique murine in vivo DF model\, where the left carotid artery (LCA) is partially ligated\, while the right carotid artery (RCA) is not surgically intervened and was the designated uniform flow (UF) control for each mouse. Diosmin treatment elevated activated endothelial NO synthase level (p-eNOS)\, inhibited inflammatory cell uptake\, decreased vessel wall thickness and increased vessel diameter\, and increased GCX coverage on the endothelium in ligated LCA. This corroborated support that diosmin protects endothelial GCX integrity and preserves complex endothelial function. \nNext\, in vitro and in vivo DF models were used to assess a novel therapy\, combining sphingosine-1-phosphate (S1P)\, a bioactive lipid mediator\, and heparin in regenerating the endothelial GCX. We used a parallel-plate flow chamber to simulate flow conditions in vitro on human coronary arterial endothelial cells (HCAECs) and a partial carotid ligation murine model to mimic DF in vivo\, as mentioned above. In vitro data showed that heparin/S1P therapy improved the function of DF-conditioned ECs by restoring the GCX and promoting EC alignment and elevated p-eNOS expression. Furthermore\, heparin/S1P treatment restored GCX in the LCA\, enhancing GCX thickness and coverage of the blood vessel wall and reducing vessel wall thickness\, demonstrating advances in a novel therapeutic that regenerates EC GCX and restores complex vascular function in DF conditions. \nThis research work is an excellent step towards the development of repurposed or novel therapeutics that can be applied to replace\, stabilize\, or protect the GCX and restore GCX-mediated EC mechanotransduction\, particularly in DF conditions. These prospective mechano-therapeutics could represent breakthrough solutions for preventing cardiovascular diseases such as atherosclerosis in the future.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-ronodeep-mitra/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240701T130000
DTEND;TZID=America/New_York:20240701T150000
DTSTAMP:20260417T053000
CREATED:20240618T190504Z
LAST-MODIFIED:20240618T190504Z
UID:4987-1719838800-1719846000@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Mohammad Hamrangsekachaee
DESCRIPTION:PhD Dissertation Defense: Endothelial Glycocalyx: Response to Fluid and Solid Mechanics in its Environment \nMohammad Hamrangsekachaee \nLocation: Snell Library 033 and Zoom \nAbstract: Atherosclerosis\, a precursor to cardiovascular diseases (CVDs)\, accounts for 37% of deaths in individuals under 70 years old\, primarily due to endothelial cell (EC) dysfunction. The glycocalyx (GCX)\, a carbohydrate-rich structure on ECs lining the vessel luminal surface\, is crucial for EC function and vascular health by regulating vascular tone\, hemostasis\, permeability\, and mechanotransduction. Therefore\, cellular models emulating the vascular mechanical environment are vital for understanding GCX’s role and its interaction with mechanical surroundings. This dissertation introduces an innovative in vitro model to investigate the combined effects of tissue stiffness and shear stress on endothelial cell function. \nTunable non-swelling gelatin-methacrylate (GelMA) hydrogels were fabricated with stiffnesses of 2.5 and 5 kPa\, representing healthy vessel tissues\, and 10 kPa\, corresponding to diseased vessel tissues. Immunocytochemistry analysis showed that on hydrogels with different levels of stiffness\, the GCX’s major polysaccharide components exhibited dysregulation in distinct patterns. For example\, there was a significant decrease in heparan sulfate expression on pathological substrates (10 kPa)\, while sialic acid expression increased with increased matrix stiffness. \nGelMA hydrogels were then integrated into a flow chamber designed to generate physiological flow conditions. The combined effects of fluid shear stress and substrate stiffness were analyzed for heparan sulfate\, sialic acid\, hyaluronic acid\, syndecan-1\, CD44\, and YAP. Under shear stress\, heparan sulfate’s coverage was reduced at 10 kPa\, while sialic acid and CD44 expression increased at 10 kPa. YAP activation\nshowed increased nuclear translocation and decreased phosphorylation at 10 kPa. Our findings revealed that substrate stiffness and mechanical forces significantly influence GCX expression and endothelial cell function. \nThis research highlights the critical role of the mechanical environment on GCX in vascular health\, particularly in the context of atherosclerosis. By developing an innovative in vitro model that integrates tissue rigidity and shear stress\, we have provided a more precise simulation of the vascular environment. This model offers a valuable tool for further understanding EC mechanotransduction and developing targeted treatments for cardiovascular diseases.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-mohammad-hamrangsekachaee/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240624T120000
DTEND;TZID=America/New_York:20240624T130000
DTSTAMP:20260417T053000
CREATED:20240617T174559Z
LAST-MODIFIED:20240617T174559Z
UID:4984-1719230400-1719234000@che.northeastern.edu
SUMMARY:Chemical Engineering Summer Sustainability Seminar Series: Ewa Marek
DESCRIPTION:Chemical looping for sustainable production of chemicals \nThe chemical industry is centred on the processing of crude oil and is responsible for the lion’s share of greenhouse gas emissions. Running industrial-scale installations requires huge energy inputs\, employing high temperatures\, pressures\, and\, often\, explosive mixtures. The current industry is designed to work continuously\, using cheap\, petrochemical feedstock. Switching the starting point and moving from oil to renewable feedstock\, whether it is bio-derived carbonaceous material\, captured CO2\, or renewable electricity\, requires new decentralised and flexible operations\, as all these resources are spatially distributed and available intermittently. Our work focuses on small-scale\, dynamic processes\, developing and employing new reaction and process pathways to produce key chemicals. This talk will present our work using a chemical looping approach where solid particles of metal oxides are the sole source of oxygen to catalytic reactions. In particular\, I will discuss the chemical looping epoxidation (CL-E) of ethylene to produce ethylene oxide (EO) and chemical looping oxidative dehydrogenation (CL-ODH) of ethanol to produce acetaldehyde. \n\nBio \nDr. Ewa Marek is an associate professor at the Department of Chemical Engineering and Biotechnology\, University of Cambridge and a fellow of Jesus College. She leads the Energy Reactions and Carriers Group\, working on the production of value-added chemicals from intermittently available renewable feedstock and electricity\, incorporating non-thermal plasma\, ultrasounds and chemical looping to drive efficient\, transient processes. This work led to 2021 Hinshelwood Prize and 2023 Energy&Fuels Rising Star Award for early-career academics. Before setting up her group\, she was a post-doctoral associate in the Engineering Department\, Cambridge\, and earlier\, she worked for six years on industrial R&D and advanced measurement methods in the UK\, Netherlands and Poland. She studied energy and chemical processing (BEng\, MSc) in Cracow and carbon capture (PhD) in Katowice (both in Poland). \nLinks \nhttps://www.ceb.cam.ac.uk/staff/dr-ewa-marek \nhttps://www.jesus.cam.ac.uk/people/ewa-marek
URL:https://che.northeastern.edu/event/chemical-engineering-summer-sustainability-seminar-series-ewa-marek/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240613T090000
DTEND;TZID=America/New_York:20240613T110000
DTSTAMP:20260417T053000
CREATED:20240611T231401Z
LAST-MODIFIED:20240611T231401Z
UID:4975-1718269200-1718276400@che.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Ian Smith
DESCRIPTION:PhD Dissertation Defense: A Primary Intestinal Model to Assay Lymphatic Drug Transport \nIan Smith \nLocation: Dodge Hall 070 & Zoom \nAbstract: Lipophilic drugs (logP > 5) often fail to develop as commercial oral medications due to poor absorption\, distribution\, metabolism\, excretion and/or toxicity (ADMET) properties. Beyond-rule-of-5 (bro5) candidate attrition in the clinic may be relieved by targeted delivery to chylomicrons (CMs) as chaperones into the mesenteric lymphatics. Lymph-cannulated animal models that estimate lymphatic bioavailability (F%) are surgically challenging\, costly and highly variable between species. In vitro models of the human intestinal epithelium can preserve enterocyte-like CM assembly and thereby recapitulate on the benchtop drug intercalation with CM components during transcytosis (i.e. the “lymphatic permeability” mechanism). This thesis proposes primary small intestinal epithelia as alternative platforms to the Caco-2 Transwell® culture for assaying lymphatic drug transport. \nPrimary monolayers cultured from small intestinal enteroids were investigated for CM synthesis\, secretion\, and transport of lymphotropic small molecules. The specific aims were to: 1) establish a mixed bile micelle formulation compatibile with primary cultures\, 2) develop a first-principle mathematical description of poorly water-soluble drug (PWSD) partitioning and uptake from lipid-containing micelles\, 3) characterize apolipoprotein B (apoB)-containing lipoprotein secretion from primary cultures along an oleic acid (OA)/2-monoloein (2-MO) stimulation axis\, and 4) compare CM-transported drug in culture to lymph-cannulated F% estimations. Exposure of mixed bile micelles containing 4:1 taurocholate (TC) and phosphatidylcholine (PC) to the brush border membrane of human duodenum (hDuo) and Caco-2/HT29-MTX co-cultures (Co-C) compromised tight junctional resistance and paracellular permeability in Co-C above 5 mM TC whereas hDuo were unaffected. Permeability measurements in the Co-C monolayer showed PWSD transport from TC/PC micelles to be reasonably predicted by changes in the apical (i.e. lumen-side) free or total drug concentration (CD\,free or CD\,total)\, but extent of fatty acid (FA)-induced supersaturation was limited by lipo-toxicity. Over a time course aligned to the window of lymph triglyceride (TG) turnover in vivo (i.e. 6 hours)\, controlled 2-monooloein (2-MO) stimulation of hDuo and murine ileum (mIle) monolayers induced significant increases in TG mass (~3.5-fold) and particle diameter (Dh) (~2-fold) of  < 1.006 g/mL lipoproteins. Primary enterocytes upregulated mgat2 transcription in the presence of 2-MO substrate to indicate that TG output in these FBS-differentiated cultures engaged the sn-1\,2-monoglyceride (2-MG) re-esterification pathway. Organoid cultures also favored basal-polarized apoB-48 release distinct from the bidirectional apoB-100 output of Caco-2. Finally\, apparent permeability of halofantrine (Hf; logP 7.34; BCS Class II) and navitoclax (Nx; logP 7.93; BCS Class IV) in CMs secreted from mIle but not Caco-2 were increased from TC/PC control conditions by inclusion of +OA/2-MO in micelles. For Hf\, the fraction of dose absorbed by CMs (faCM = 6.8 ± 0.9%) was similar to the fraction of dose transported into the lymph of cannulated rats (falymph = 5.5 ± 0.8%). \nDevelopment of an in vitro-in vivo correlation between lymph-cannulated animals and the primary transport assay developed herein might assist preclinical programs in translating lipid-based oral modalities to humans. Expansion of the organoid donor set (by species and small intestinal region)\, combinatorial probing of more lipid stimulation axes (by substrate chain length and saturation)\, and scaling of monolayer culture could refine the lymphatic assay into a high-throughput screen. Beyond a drug delivery context\, de novo CM assembly in enterocytes that retain a native small intestinal phenotype enables closed-system study of outstanding questions regarding intestinal lipoprotein formation and dyslipidemia disease intervention.
URL:https://che.northeastern.edu/event/che-phd-dissertation-defense-ian-smith/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240426T120000
DTEND;TZID=America/New_York:20240426T130000
DTSTAMP:20260417T053000
CREATED:20240424T004036Z
LAST-MODIFIED:20240424T004036Z
UID:4871-1714132800-1714136400@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Seminar Series: Dr. David Brayden
DESCRIPTION:Oral administration of peptides: The quest to improve bioavailability \nThe oral administration of peptides and proteins remains one of the great challenges in pharmaceutical science. Efficacy depends on patients committing to take essential medicines and this is built upon the convenience of a dosing regimen using a patient-friendly route of administration. Large molecules have problems negotiating the GI tract to achieve systemic delivery due to instability against metabolizing enzymes and low permeability across the epithelium. To date\, just five linear peptides aimed at systemic delivery have been approved by the FDA\, the most recent being oral semaglutide (Rybelsus®\, Novo Nordisk\, 2019) and oral octreotide (Mycappsa®\, Chiasma Ltd\, 2020). These approvals heralded a renewed interest in the field\, built around developing Glucagon-1-like peptide 1 (GLP-1) mimetics for Type II diabetes and obesity\, alone or as a dual agonist with other gut peptides. Relative success to date for oral peptides has been achieved with standard oral dosage forms made with permeation enhancers\, but these will only work for niche peptides with high potency and long half-lives. \nMy group has been working on the mechanism of action of the intestinal permeation enhancers that typically are used to enable these formulations\, albeit that oral bioavailability with the above products is less than 1%. We have focussed on comparisons between sodium caprate and SNAC\, both medium-chain fatty acid derivatives\, and found that they have multimodal actions suggesting a dual effects on tight junctions and the intestinal epithelial plasma membrane depending on the concentration and the bioassay. We also have contributed to the search for other permeation enhancers (alone and combination) that can be used with peptides in oral dosage forms including the Gattefosse excipients\, Labrasol® and Labrafac™. We are working on a nanotechnology concept\, where we have achieved 7% bioavailability for insulin in a rat model using a core-shell construct based on silica coating over a core of peptide and the excipients\, L-arginine\, and zinc. Finally\, devices may eventually be able to increase the oral bioavailability of peptides by an order of magnitude over permeation enhancers according to data from animal models\, but clinical testing is at an early stage and the toxicology and the regulatory pathway for these types of technologies have yet to be addressed. I will touch on aspects and examples of these multiple approaches in my talk at Northeastern. \n\nDavid Brayden is Full Professor of Advanced Drug Delivery at the School of Veterinary Medicine and a Fellow of the UCD Conway Institute. Following a Ph.D. in Pharmacology at the University of Cambridge\, UK (1989)\, and a post-doctoral research fellowship at Stanford University\, CA (1991)\, he set up Elan Corporation’s pharmacology laboratory in Dublin (1991). At Elan\, he became a senior scientist and project manager of several of Elan’s Joint-Venture drug delivery research collaborations with US biotech companies. In 2001\, he joined UCD as a college lecturer in veterinary pharmacology and was appointed Senior Lecturer (2005)\, Associate Professor (2006)\, and Full Professor (2014). He completed a successful Principle Investigator Grant from SFI on the topic of oral delivery of novel mucoadhesive polymeric peptide conjugates (2005-2009). Professor Brayden was the Director of an SFI Research Cluster grant (The Irish Drug Delivery Research Network)\, that was awarded 7.2 million euro by SFI from 2007-2013. He was the Deputy Coordinator of an EU 7th Framework grant on oral nanomedicines (www.TRANS-INT.eu)\, 2012-2017. In 2014\, he was one of four Principal Investigators (Co-PIs) on the successful SFI Centre bid in Medical Devices (CURAM)\, worth over 40 million EUR over 6 years\, which was renewed for 6 years in 2021. He is the coordinator of the Horizon Europe consortium grant\, BUCCAL-PEP\, which was awarded 4m EUR and runs from 2022-2026. He is the author or co-author of more than 300 research publications and patents. Professor Brayden serves on the Editorial Advisory Boards of Drug Discovery Today\, Advanced Drug Delivery Reviews and the Journal of Veterinary Pharmacology and Therapeutics. In 2021 he was appointed Chief Editor of “Frontiers in Drug Delivery”. He was Chairman of the UK-Ireland Chapter of the Controlled Release Society (2003-2006)\, Co-Chair of the Veterinary Programmes at the CRS international conferences (2003-2006)\, and served on the CRS Board of Scientific Advisors (2006-2009) and the CRS Annual Meeting Programme Committee (2015\, 2016). At UCD\, he was Chairman of the Animal Research Ethics Committee (2005-2007) and was a member of the UCD Research Ethics Committee (2006-2011) and was elected by Academic Council to the UCD Promotions and Tenure Committee (2010-2012) and to the UCD Academic Council for Academic Centres Committee\, ACCAC (2019-). He was Director of Research for the School of Agriculture\, Food Science and Veterinary Medicine (2007-2008) and Head of the Veterinary Biosciences Section from 2013-2017. On the teaching side\, he coordinates undergraduate and postgraduate modules on Biological Fluids and Drug Discovery and Development and contributes to a module on Cell Communication. He contributes Professional Ethics material to the Conway Institute Core Research Skills modules and also coordinates a 4th level online module on Drug Discovery and Development. In 2015\, he was made an Adjunct Professor at NUI Galway to support his Co-PI role in the SFI CURAM Centre. He was elected as a Fellow of both the Controlled Release Society (2012) and the American Association of Pharmaceutical Scientists (2017). In 2021\, he was appointed by the Minister of Health to the National Research Ethics Committee (Clinical Trials A). He acts as a consultant to selected Pharma and Biotech companies.
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-dr-david-brayden/
LOCATION:024 East Village\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3396156;-71.0886534
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240417T133000
DTEND;TZID=America/New_York:20240417T143000
DTSTAMP:20260417T053000
CREATED:20240405T203435Z
LAST-MODIFIED:20240406T012745Z
UID:4834-1713360600-1713364200@che.northeastern.edu
SUMMARY:Soft Matter Days
DESCRIPTION:Soft Matter Days: April 8-17\, will feature invited guest speakers discussing a variety of interdisciplinary topics in soft matter and complex fluids.  These topics sit at the interface of chemical & mechanical engineering\, materials science\, physics\, chemistry\, and biology.  Guest speakers will discuss real-world phenomena found in food\, blood flow\, and granular materials.  Two talks are guest lectures in CHME5179: RSVP required for those not in the class. \nMonday\, April 8\, 2:15pm\, Curry 340\nCapillary Rise and Thin Films Near Edges: New Insights from Self-similarity\nHoward Stone\, Princeton University\nHost: Xiaoyu Tang x.tang@northeastern.edu \nTuesday\, April 9\, 9:50am\, Zoom (Guest Lecture for CHME 5179)\n“Complex Fluids & Soft Matter in Food”\nDave Weitz\, Harvard University\nRSVP: Sara Hashmi s.hashmi@northeastern.edu \nThursday\, April 11\, 1:30pm\, HS 210\nDynamics of blood flow at the cellular level in health and disease\nMichael Graham\, University of Wisconsin\nHost: Sara Hashmi s.hashmi@northeastern.edu \nFriday\, April 12\, 9:50am\, Zoom (Guest Lecture for CHME 5179)\nNonlinear Rheology of Complex Fluids: Exploring Microstructure\nKate Honda\, Northeastern University\nRSVP: Sara Hashmi s.hashmi@northeastern.edu \nWednesday\,  April 17\, 1:30pm\, HS 210\nUniversality and scaling in shear thickening suspensions\nBulbul Chakraborty\, Brandeis University\nHost: Sara Hashmi s.hashmi@northeastern.edu
URL:https://che.northeastern.edu/event/soft-matter-days/2024-04-17/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240410T120000
DTEND;TZID=America/New_York:20240410T130000
DTSTAMP:20260417T053000
CREATED:20240328T195531Z
LAST-MODIFIED:20240328T195531Z
UID:4827-1712750400-1712754000@che.northeastern.edu
SUMMARY:Chemical Engineering Spring Seminar Series: Dr. Jodie Lutkenhaus
DESCRIPTION:Organic Batteries for a More Sustainable Future \nCobalt\, nickel\, and lithium are essential ingredients in today’s lithium-ion batteries (LIBs)\, but their continued use presents economic\, ethical\, and environmental challenges. Society must now begin to consider the implications of a LIB’s full life cycle\, including the carbon footprint\, the economic and environmental costs\, and material access. These challenges motivate the case for degradable or recyclable batteries sourced from earth-abundant materials whose life cycle bears minimal impact on the environment. This presentation considers organic polymer-based batteries\, which have the potential to address many of these issues. Redox-active polymers form the positive and negative electrodes\, storing charge through a reversible redox mechanism. We demonstrate polypeptide radical batteries that degrade on command into amino acids and by-products as a first step toward circular organic batteries. Further\, we show the recycling of redox-active polymer electrodes using a solvent-based approach. Polymer-air batteries are examined as high-capacity alternatives to metal-air batteries. The molecular mechanism for each case is investigated\, revealing pathways forward for improving each polymer’s performance. Taken together\, organic batteries offer the promise of a circular platform free of critical elements. \n\nJodie L. Lutkenhaus is a Professor\, Associated Department Head\, and holder of the Axalta Chair in the Artie McFerrin Department of Chemical Engineering at Texas A&M University. Lutkenhaus received her B.S. in 2002 from The University of Texas at Austin and her Ph.D in 2007 from the Massachusetts Institute of Technology. Current research areas include polyelectrolytes\, redox-active polymers\, energy storage\, and composites. She has received recognitions including World Economic Forum Young Scientist\, Kavli Fellow\, NSF CAREER\, AFOSR Young Investigator\, and the 3M Non-tenured Faculty Award. She is the past-Chair of the AICHE Materials Engineering & Sciences Division. Lutkenhaus is the Deputy Editor of ACS Applied Polymer Materials and a member of the U.S. National Academies Board of Chemical Sciences & Technology.
URL:https://che.northeastern.edu/event/chemical-engineering-spring-seminar-series-dr-jodie-lutkenhaus/
LOCATION:103 Churchill\, 103 Churchill Hall\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3387735;-71.0889235
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=103 Churchill 103 Churchill Hall 360 Huntington Ave Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=103 Churchill Hall\, 360 Huntington Ave:geo:-71.0889235,42.3387735
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240408T141500
DTEND;TZID=America/New_York:20240408T143000
DTSTAMP:20260417T053000
CREATED:20240406T003435Z
LAST-MODIFIED:20240406T012740Z
UID:4832-1712585700-1712586600@che.northeastern.edu
SUMMARY:Soft Matter Days
DESCRIPTION:Soft Matter Days: April 8-17\, will feature invited guest speakers discussing a variety of interdisciplinary topics in soft matter and complex fluids.  These topics sit at the interface of chemical & mechanical engineering\, materials science\, physics\, chemistry\, and biology.  Guest speakers will discuss real-world phenomena found in food\, blood flow\, and granular materials.  Two talks are guest lectures in CHME5179: RSVP required for those not in the class. \nMonday\, April 8\, 2:15pm\, Curry 340\nCapillary Rise and Thin Films Near Edges: New Insights from Self-similarity\nHoward Stone\, Princeton University\nHost: Xiaoyu Tang x.tang@northeastern.edu \nTuesday\, April 9\, 9:50am\, Zoom (Guest Lecture for CHME 5179)\n“Complex Fluids & Soft Matter in Food”\nDave Weitz\, Harvard University\nRSVP: Sara Hashmi s.hashmi@northeastern.edu \nThursday\, April 11\, 1:30pm\, HS 210\nDynamics of blood flow at the cellular level in health and disease\nMichael Graham\, University of Wisconsin\nHost: Sara Hashmi s.hashmi@northeastern.edu \nFriday\, April 12\, 9:50am\, Zoom (Guest Lecture for CHME 5179)\nNonlinear Rheology of Complex Fluids: Exploring Microstructure\nKate Honda\, Northeastern University\nRSVP: Sara Hashmi s.hashmi@northeastern.edu \nWednesday\,  April 17\, 1:30pm\, HS 210\nUniversality and scaling in shear thickening suspensions\nBulbul Chakraborty\, Brandeis University\nHost: Sara Hashmi s.hashmi@northeastern.edu
URL:https://che.northeastern.edu/event/soft-matter-days/2024-04-08/
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END:VCALENDAR