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DTSTART;TZID=America/New_York:20201104T120000
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SUMMARY:Engineered Models of the Enteric-Gut-Axis
DESCRIPTION:ChE Seminar Series Presents:   \nAbigail N. Koppes\, Ph.D.\nAssistant Professor\, Department of Chemical Engineering\nAffiliate in Biology and Bioengineering \n“Engineered Models of the Enteric-Gut-Axis” \nAbstract: The gut-brain-axis is a complex bi-directional communication pathway between the gastrointestinal tract\, the enteric nervous system (ENS)\, and the central nervous system (CNS) that is implicated in not only gastrointestinal function but also cognitive tasks like memory and decision making. Gastrointestinal flora has also been implicated in alterations of brain function and behavior\, however\, mechanisms behind the gut-to-brain communication remain poorly understood. To investigate the mechanisms for epithelial/neural interactions in the gastrointestinal tract and understand the impact of alterations in neural activity in response to intestinal contents\, we are developing in vitro humanized culture models of the enteric-gut axis. These platforms\, termed “Microphysiological Systems or Organ-Chips” have generated interest from academia and industry as these physiological models may augment drug and basic biological discoveries. However\, the lack of rapid\, scalable\, and facile manufacturing techniques may limit the widespread use of organs-on-chips. Here I will discuss a novel laser-cut and assembly-based fabrication method for simple\, and cost-effective thermoplastic organ-chips. It has also been proposed that seeding patient-derived cells will enable personalized medicine\, but current intestine-on-a-chip models often utilize immortalized cells and rarely include support cells such as enteric neurons. Finally\, I will discuss the culture and differentiation of a primary\, human epithelial monolayer from patient-derived intestinal organoids for on-chip studies that recapitulate the heterogeneous gut population\, and the impact of trophic cross-talk between the epithelium and enteric populations in static models. \nBiography: Dr. Abigail Koppes joined the department of Chemical Engineering at Northeastern University in 2014 where her group\, the Advanced Biomaterials for Neuroengineering Laboratory (ABNEL)\, harnesses biochemical engineering methods to address challenges in nervous system disorders and dysfunction. She was the recipient of the NIH R21 Trailblazer in 2017\, is a co-investigator on a 2019 AHA Innovative Project Award and is a co-investigator on a 2016 NIH Biomedical Research Partnership R01 between Northeastern\, MIT\, and Boston Children’s Hospital. She received the 2020 BMES Rita Shaffer Young Investigator and CMBE Young Innovator Award in 2020. She received her Ph.D. in Biomedical Engineering from Rensselaer Polytechnic Institute (RPI) in Troy\, New York in 2013. Her doctoral research with Dr. Deanna Thompson focused on using electrical stimulation to manipulate neural and supportive glial cell behavior for improved repair following peripheral nervous system injuries. In 2013\, Dr. Koppes joined the Advanced Drug Delivery Research Laboratory with Dr. Rebecca Carrier as the Northeastern University NSF ADVANCE Future Faculty Fellow and held a joint appointment at Schepen’s Eye Research Institute and Harvard Medical School with Dr. Michael Young and as a visiting scientist in Dr. Douglas Lauffenburger’s Molecular Cell Bioengineering group at MIT. At Northeastern Dr. Koppes enjoys teaching Design 1 Lab (Unit Operations Transport I) for undergraduate engineers and Design of Experiments and Ethical Research for graduate students\, where she is a member of the DEI and graduate committees\, as well as has mentored over 40 undergraduates in the laboratory. She also currently serves on the BMES Diversity Committee. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/engineered-models-of-the-enteric-gut-axis/
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DTSTART;TZID=America/New_York:20201104T123000
DTEND;TZID=America/New_York:20201104T130000
DTSTAMP:20260417T193554
CREATED:20201031T005754Z
LAST-MODIFIED:20201031T005754Z
UID:3406-1604493000-1604494800@che.northeastern.edu
SUMMARY:Magic or Magnetics? Novel Materials for Energy Transfer
DESCRIPTION:ChE Seminar Series Presents:  \nLaura H. Lewis\, Ph.D.\nDistinguished University and Cabot Professor\,  Chemical Engineering\nDistinguished University and Cabot Professor\,  Mechanical and Industrial Engineering \n“Magic or Magnetics? Novel Materials for Energy Transfer” \nAbstract: Magnetic materials permit the wireless interconversion of electrical\, mechanical and\, increasingly\, thermal energies to benefit an enormous breadth of technologies including sustainable energy\, e-mobility\, data storage and biomedicine. Magnetic performance may be controlled through engineering at the atomic\, nanoscopic and microstructural levels\, providing a vast arena for realization of new types of magnetic materials. This presentation provides a brief overview of selected research activities\, with focus on recent progress to realize a new material\, tetrataenite\, that holds promise as a new advanced permanent magnet free of critical\, geopolitically constrained elements. \nBiography: Laura H. Lewis is a Distinguished University and Cabot Professor of Chemical Engineering and Profes¬sor of Mechanical and Industrial Engineering at Northeastern University in Boston\, MA\, U.S.A. Prior to her faculty position at Northeastern University\, she was a research group leader and Associate Department Chair in the Nanoscience Department of Brookhaven National Laboratory (BNL)\, a U.S. Department of Energy Laboratory devoted to research in the physical\, biomedical\, and environmental sciences\, as well as in energy technologies. Concurrently\, she was the Deputy Director of the BNL Center for Functional Nanomaterials\, a DOE national user facility to provide researchers with state-of-the-art capabilities to fabricate and study nanoscale materials. Laura received her Ph.D. in Materials Science and Engineering from the University of Texas at Austin; she earned a M.S. degree in Electronic Materials from M.I.T. and a B.S. degree in Physics and Earth Sciences from the University of California at San Diego. \nLaura’s research focuses on investigating the materials factors at the atomic level that provide functionality to magnetic materials\, with a specialization in sustainable elements and rare earths. She has authored over 200 peer-reviewed publications and delivered over 100 invited presentations at national and international venues. She has participated on a number of advisory panels\, most recently as am Advisory Board Member of the Critical Materials Institute\, A DOE Energy Innovation Hub\, the IEEE Magnetics Society AdCom and International Advisory Committee of the Joint European Magnetics Symposia. She has been appointed as a member of the U.S. Technical Advisory Group to the ISO/TC 298 Standard for Rare Earth that will determine the U.S. position on standardization in the field of rare earth mining\, concentration\, extraction\, separation and conversion to useful rare earth compounds/materials which are key inputs to manufacturing and technologies. \nLaura is a Senior Member of the IEEE and served as Conference Editor of the IEEE Transactions on Magnetics (2008 – 2018) and Chair of the IEEE Magnetics Society Technical Committee (2017 – 2019). She is a Fellow of the American Physical Society\, a Fulbright Fellow as well as a member of the Materials Research Society\, the American Chemical Society and the American Society for Engineering Education. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/magic-or-magnetics-novel-materials-for-energy-transfer/
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