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SUMMARY:ChE Seminar Series Presents: “Engineering the intestinal and retinal microenvironments”
DESCRIPTION:ChE Seminar Series Presents:\n \nRebecca Carrier\, Ph.D. \nProfessor & Associate Chair of Research\, Department of Chemical Engineering \nAffiliated Faculty\, Bioengineering\, Northeastern University\, Boston\, MA \n“Engineering the intestinal and retinal microenvironments” \nAbstract: The Advanced Drug Delivery Lab conducts research in regenerative medicine\, with a focus on intestinal and retinal tissue engineering\, and in oral drug delivery\, with a focus on enabling effective oral delivery of therapeutics. In the area of enabling effective oral drug delivery\, we have developed an experimental and theoretical framework to predict the impact of ingested lipids\, in food or drug delivery systems\, on oral drug absorption. This work could have a significant impact on societal health by providing practical\, relevant guidance for the oral dosing of drugs and nutritive supplements. As part of our efforts in enabling effective oral treatments\, we have explored the barrier properties of the gastrointestinal mucus barrier\, and revealed changes in the mucus barrier certain disease states. The lab is now exploring how to alter mucus barrier properties to potentially prevent certain diseases\, including necrotizing enterocolitis. In the area of intestinal tissue engineering\, we are developing human in vitro models of the microbiome-gut-immune axis for understanding the impact of what we ingest and the microbiome on human health. We are also developing biomaterial cell carriers for cell-therapy based retinal regeneration strategies\, with a focus on engineering cues into biomaterial carriers that will promote the survival and integration of implanted cells. \nBiosketch: Rebecca Carrier is a Professor in the Department of Chemical Engineering at Northeastern. She earned a BS in Chemical Engineering from Rensselaer Polytechnic Institute in 1995\, and a Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology in 2000\, where she worked as a pioneer in cardiac muscle tissue engineering. After completing her graduate studies\, Rebecca worked at Pfizer\, Inc.\, as a Senior Research Scientist in oral controlled release drug delivery. She joined Northeastern in 2003\, and the overall theme of her research interests is the interaction between biological systems and materials\, with specific applications in drug delivery and regenerative medicine. She has worked with multiple industrial partners including Pfizer\, Merck\, and Boehringer Ingelheim\, and has received honors including the NSF CAREER award\, NU “Outstanding Teacher (2011)\,” “Faculty Fellow (2014)\,” and Soren Buus Outstanding Research (2017) Awards for excellence in teaching and research leadership. She was also invited to participate in the National Academy of Engineering Frontiers of Engineering (2016) and Frontiers of Engineering Education (2013) Symposia\, served as the Member-At-Large for the Society for Biomaterials from 2018-2019\, and was inducted into the American Institute for Medical and Biological Engineering in 2019. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-series-presents-engineering-the-intestinal-and-retinal-microenvironments/
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LAST-MODIFIED:20201005T191523Z
UID:3340-1602073800-1602075600@che.northeastern.edu
SUMMARY:ChE Seminar Series Presents: “Engineering Bacteria to Solve Problems in Renewable Chemical Production and Human Health”
DESCRIPTION:ChE Seminar Series Presents:\n \nBenjamin M. Woolston\, PhD \nAssistant Professor\, Department of Chemical Engineering\, Northeastern University\, Boston \, MA \n“Engineering Bacteria to Solve Problems in Renewable Chemical Production and Human Health” \nAbstract: The synthetic biology revolution has given us the ability to genetically reprogram microbes to serve a wide variety of purposes – from miniscule chemical factories that orchestrate exquisitely selective enzymatic pathways to produce fuels\, pharmaceuticals and polymers from simple raw materials – to biological computers that can sense their chemical environment and implement complex decision-making algorithms. The overall goal of the Woolston lab is to harness this potential for applications in renewable energy production and the human gut microbiota. In this talk\, I will present an overview of the two major current thrusts of the lab: In the first\, we are engineering anaerobic bacteria for the conversion of renewable single-carbon feedstocks to biofuels\, taking advantage of a number of economic and ethical benefits of using these substrates compared to 1st and 2nd generation biofuel efforts. In the second\, we are developing engineered microbes that can sense and correct an overabundance of the microbially derived metabolite hydrogen sulfide in the human gut; a toxic\, volatile molecule implicated in the onset of IBD and colorectal cancer. As well as the exciting applied potential of the resultant technology\, these efforts will also provide us with model systems with which to answer broader fundamental questions about microbial metabolism. \nBiography: Dr. Woolston joined the NEU Chemical Engineering department as an Assistant Professor in January 2020. As an NSF Graduate Research Fellow\, Dr. Woolston received his PhD in Chemical Engineering in 2017 from MIT under the guidance of Prof. Greg Stephanopoulos\, where his research focused on the development of genetic tools to enable metabolic engineering in anaerobic CO2-fixing microbes\, and the establishment of a methanol utilization pathway in the model organism Escherichia coli. While at MIT\, he was an inaugural Fellow of the Chemical Engineering Communication Lab\, where he provided peer tutoring and department-wide workshops to assist students and post-docs with aspects of scientific communication. His Post-doctoral work was conducted in the laboratory of Prof. Emily Balskus in the Chemistry & Chemical Biology department at Harvard University\, where he studied microbial metabolic pathways and enzymes that contribute to the stability of health-associated Lactobacilli in the human vaginal microbiota. At Northeastern\, his research program combines approaches from his previous research training in metabolic engineering\, synthetic biology\, biochemistry and microbiology to engineer microbes for biofuel & biochemical production\, and as diagnostics and therapeutics in the Human gut microbiota. His lab team currently consists of three graduate students and two undergraduates. Since joining NEU\, Dr. Woolston has taught the Biochemical Engineering senior elective (CHME 5630) and the graduate course in Kinetics & Reactor Design (CHME 7340). \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-series-presents-engineering-bacteria-to-solve-problems-in-renewable-chemical-production-and-human-health/
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