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DTSTART;TZID=America/New_York:20200930T120000
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SUMMARY:ChE Seminar: "Engineering the Production of Medicinal Natural Products from Plant Cell Cultures"
DESCRIPTION:ChE Seminar Series Presents:\n \nCarolyn W.T. Lee-Parsons\, Ph.D. \nAssociate Professor\, Chemical Engineering Department; Chemistry & Chemical Biology Department\, Northeastern University\, Boston\, MA \n“Engineering the Production of Medicinal Natural Products from Plant Cell Cultures” \nAbstract: \nMany plant-derived pharmaceuticals are currently supplied by extracting the plant material.  Due to the slow growth rates or low product concentrations in plants\, finding an alternative route for supplying these critical drugs is necessary.  The overall vision of this research is to enhance the production of critical plant-derived pharmaceutical compounds through genetically engineered plant cell cultures\, specifically using the production of terpenoid indole alkaloids (TIAs) from cultures of Catharanthus roseus as a model system.  The C. roseus plant produces several highly valued pharmaceuticals\, including the anti-cancer drugs vincristine and vinblastine.  The high cost and need for these pharmaceuticals motivate our research to better understand their biosynthesis and ultimately overproduce these compounds using C. roseus cultures.  In this talk\, I will present our research in exploring how TIA biosynthesis is regulated and how this knowledge leads to developing synthetic biology strategies for manipulating TIA production. \nBiography: \nCarolyn W.T. Lee-Parsons is an Associate Professor jointly appointed in the Departments of Chemical Engineering and of Chemistry and Chemical Biology at Northeastern University.  She earned her B.S. from the University of Kansas and her Ph.D. from Cornell University\, both in Chemical Engineering.  As an undergraduate\, she modeled reaction networks with Prof. Bala Subramaniam and investigated oil and gas recovery strategies at ARCO Oil and Gas. Growing up in the midst of wheat fields in Kansas\, she was always intrigued by plants and specifically medicines from plants.  As a doctoral student\, she investigated bioprocess strategies for increasing the production of medicines from plant cell cultures with Prof. Michael L. Shuler. \nHer current research area is in plant metabolic engineering and plant synthetic biology.  Her team of graduate and undergraduate students focus on understanding how plants regulate the production of specialized metabolites and on developing and applying tools for engineering the production of pharmaceutical compounds and biofuels from plant tissue cultures and microalgae cultures.  Carolyn seeks to engage majors across disciplines in understanding the fundamentals underlying life in living organisms and translating this understanding to developing solutions to society’s grand challenges.  She contributed to the revision of the widely used textbook for bioprocess engineering (Bioprocess Engineering:  Basic Concepts by M.L. Shuler\, F. Kargi\, and M. DeLisa).  For her teaching and research mentoring\, she was awarded the Martin Essigmann Outstanding Teaching Award and the University Excellence in Teaching Award at Northeastern University. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-engineering-the-production-of-medicinal-natural-products-from-plant-cell-cultures/
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DTSTART;TZID=America/New_York:20200930T123000
DTEND;TZID=America/New_York:20200930T130000
DTSTAMP:20260405T075854
CREATED:20200926T001515Z
LAST-MODIFIED:20200926T001515Z
UID:3322-1601469000-1601470800@che.northeastern.edu
SUMMARY:ChE Seminar: "Engineering Innervated Organ Systems"
DESCRIPTION:ChE Seminar Series Presents:   \nRyan Koppes\, Ph.D. \nAssistant Professor\, Department of Chemical Engineering\, Northeastern University\, Boston\, MA \n“Engineering Innervated Organ Systems” \nAbstract:   \nMicrophysiological systems (MPS) hold the potential to provide benchtop models to investigate fundamental biology and disease while reducing the need for animal models. However\, many conventional in vitro models fail to fully capture the complex cell-cell interactions\, 3D microenvironments\, structural organization\, or vascularization of multicellular organ systems. A key criterion for replicating physiologically relevant architectures in a dish is the ability to compartmentalize discrete cell populations\, extracellular matrix compositions\, and/or mechanical properties\, without meaningfully restricting auto- and paracrine signaling. Traditionally\, compartmentalization within MPS has relied on the use of posts or microtunnels fabricated in silicon-based materials\, often requiring expensive lithographic capabilities. Further\, these methods are commonly limited to confining discrete tissues in the x-y plane. Towards overcoming these limitations\, we have developed a new ‘cut & assemble’ manufacturing technique. We have utilized these new tools to establish a number of MPS platforms to model the cardiovascular system. As part of this talk\, I will highlight the potential of this new technology and how we have applied it to model the heart and the adrenal medulla at the benchtop. Further\, through our work\, I will demonstrate how important the inclusion of neuron populations are for recapitulating organ function. \nBiography: \nDr. Ryan Koppes has been an Assistant Professor at Northeastern University since 2015\, where he has founded the Laboratory for Neuromodulation and Neuromuscular Repair (LNNR). Ryan received his Ph.D. in Biomedical Engineering from Rensselaer Polytechnic Institute (RPI) in Troy\, New York in 2013. His doctoral research with Dr. David Corr focused on soft musculoskeletal biomechanics and tissue engineering. In 2013\, Dr. Koppes joined the Bioelectronics Laboratory with Dr. Polina Anikeeva in Material Science and Engineering at MIT\, where he worked as a Translational Fellow on neural interface technology utilizing a multimaterial thermal drawing process and optogenetics. He was the recipient of the NIH R21 Trailblazer in 2017\, is a co-investigator on a 2019 AHA Innovative Project Award\, an NSF I-Corps\, and is a co-investigator on a 2020 NIH BRAIN Initiative R01 between Northeastern\, UCLA\, and Boston Children’s Hospital. Dr. Koppes also enjoys teaching Chemical Engineering Experimental Design Lab II (Unit Operations II) for senior engineers\, as well as mentoring undergraduates in the laboratory. \nPlease email Alyssa Ramsey at a.ramsey@northeastern.edu for the link to the seminar.
URL:https://che.northeastern.edu/event/che-seminar-engineering-innervated-organ-systems/
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